Lymphocyte/macrophage interactions on surface modified biomaterial surfaces

An in vitro lymphocyte/macrophage co-culture system was developed and the modes and time-dependent cell/cell interactions were characterized. It was found that hydrophilic surface chemistries down-regulate both lymphocyte and macrophage responses to biomaterials. The presence of macrophages in cultures significantly enhanced lymphocyte proliferation rates. The results suggested that the role of lymphocytes and macrophases in the foreign body response must be considered when designing biomaterials. It was also suggested that hydrophilic surfaces down-regulate both macrophage and lymphocyte responses and should be considered for implantable devices and prostheses.