Lymphocyte-to-monocyte ratio predicts survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Eric Pletcher; Elizabeth Gleeson; Tali Shaltiel; Natasha Leigh; Brianne Sullivan; Daniel Labow; Deepa Magge; Benjamin Golas; Noah Cohen; Umut Sarpel

doi:10.2217/bmm-2020-0720

Lymphocyte-to-monocyte ratio predicts survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Eric Pletcher, Elizabeth Gleeson, Tali Shaltiel, Natasha Leigh, Brianne Sullivan, Daniel Labow, Deepa Magge, Benjamin Golas, Noah Cohen, Umut Sarpel

Section of Surgical Oncology

Research output: Contribution to journal › Article › peer-review

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Abstract

Aim: Lymphocyte-to-monocyte ratio (LMR) predicts overall survival (OS) in patients with colorectal cancer. We explored LMR in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). Materials & methods: We identified all patients undergoing CRS/HIPEC for colorectal or appendiceal adenocarcinoma at our institution. We analyzed LMR's relationship with clinicopathologic variables with Kaplan-Meier log-rank survival analyses and multivariable Cox regression models with 5-year OS. Results: Two hundred and sixteen patients underwent CRS/HIPEC. Five-year OS for low LMR (≤3.71) was 35.2 versus 60.4% for elevated LMR (hazard ratio [HR]: 2.0; 95% CI: 1.1-3.5; p = 0.02). On multivariable Cox-regression, elevated LMR was significantly associated with OS (p ≤ 0.05). Conclusion: LMR is an independent predictor of OS in patients undergoing CRS/HIPEC for colorectal and appendiceal adenocarcinoma.

Original language	English
Pages (from-to)	965-975
Number of pages	11
Journal	Biomarkers in Medicine
Volume	15
Issue number	12
DOIs	https://doi.org/10.2217/bmm-2020-0720
State	Published - Aug 2021

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@article{401a7cb4de8e417a9863a66e6888195e,

title = "Lymphocyte-to-monocyte ratio predicts survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy",

abstract = "Aim: Lymphocyte-to-monocyte ratio (LMR) predicts overall survival (OS) in patients with colorectal cancer. We explored LMR in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). Materials & methods: We identified all patients undergoing CRS/HIPEC for colorectal or appendiceal adenocarcinoma at our institution. We analyzed LMR's relationship with clinicopathologic variables with Kaplan-Meier log-rank survival analyses and multivariable Cox regression models with 5-year OS. Results: Two hundred and sixteen patients underwent CRS/HIPEC. Five-year OS for low LMR (≤3.71) was 35.2 versus 60.4% for elevated LMR (hazard ratio [HR]: 2.0; 95% CI: 1.1-3.5; p = 0.02). On multivariable Cox-regression, elevated LMR was significantly associated with OS (p ≤ 0.05). Conclusion: LMR is an independent predictor of OS in patients undergoing CRS/HIPEC for colorectal and appendiceal adenocarcinoma.",

author = "Eric Pletcher and Elizabeth Gleeson and Tali Shaltiel and Natasha Leigh and Brianne Sullivan and Daniel Labow and Deepa Magge and Benjamin Golas and Noah Cohen and Umut Sarpel",

year = "2021",

month = aug,

doi = "10.2217/bmm-2020-0720",

language = "English",

volume = "15",

pages = "965--975",

journal = "Biomarkers in Medicine",

issn = "1752-0363",

number = "12",

}

TY - JOUR

T1 - Lymphocyte-to-monocyte ratio predicts survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

AU - Pletcher, Eric

AU - Gleeson, Elizabeth

AU - Shaltiel, Tali

AU - Leigh, Natasha

AU - Sullivan, Brianne

AU - Labow, Daniel

AU - Magge, Deepa

AU - Golas, Benjamin

AU - Cohen, Noah

AU - Sarpel, Umut

PY - 2021/8

Y1 - 2021/8

N2 - Aim: Lymphocyte-to-monocyte ratio (LMR) predicts overall survival (OS) in patients with colorectal cancer. We explored LMR in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). Materials & methods: We identified all patients undergoing CRS/HIPEC for colorectal or appendiceal adenocarcinoma at our institution. We analyzed LMR's relationship with clinicopathologic variables with Kaplan-Meier log-rank survival analyses and multivariable Cox regression models with 5-year OS. Results: Two hundred and sixteen patients underwent CRS/HIPEC. Five-year OS for low LMR (≤3.71) was 35.2 versus 60.4% for elevated LMR (hazard ratio [HR]: 2.0; 95% CI: 1.1-3.5; p = 0.02). On multivariable Cox-regression, elevated LMR was significantly associated with OS (p ≤ 0.05). Conclusion: LMR is an independent predictor of OS in patients undergoing CRS/HIPEC for colorectal and appendiceal adenocarcinoma.

AB - Aim: Lymphocyte-to-monocyte ratio (LMR) predicts overall survival (OS) in patients with colorectal cancer. We explored LMR in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). Materials & methods: We identified all patients undergoing CRS/HIPEC for colorectal or appendiceal adenocarcinoma at our institution. We analyzed LMR's relationship with clinicopathologic variables with Kaplan-Meier log-rank survival analyses and multivariable Cox regression models with 5-year OS. Results: Two hundred and sixteen patients underwent CRS/HIPEC. Five-year OS for low LMR (≤3.71) was 35.2 versus 60.4% for elevated LMR (hazard ratio [HR]: 2.0; 95% CI: 1.1-3.5; p = 0.02). On multivariable Cox-regression, elevated LMR was significantly associated with OS (p ≤ 0.05). Conclusion: LMR is an independent predictor of OS in patients undergoing CRS/HIPEC for colorectal and appendiceal adenocarcinoma.

UR - http://www.scopus.com/inward/record.url?scp=85112151755&partnerID=8YFLogxK

U2 - 10.2217/bmm-2020-0720

DO - 10.2217/bmm-2020-0720

M3 - Article

C2 - 34289740

AN - SCOPUS:85112151755

SN - 1752-0363

VL - 15

SP - 965

EP - 975

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 12

ER -

Lymphocyte-to-monocyte ratio predicts survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

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