Lymphoblastic leukemia with mature B-cell phenotype in infancy

John L. Frater, Jacqueline R. Batanian, Dennis M. O'Connor, Leonard E. Grosso

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Lymphoblastic leukemias with surface immunoglobulin light chain expression and L1/L2 blast morphology (French-American-British Classification) are rare. The poor prognosis of lymphoblastic leukemia in children under 1 year of age is attributed largely to rearrangements involving the mixed lineage leukemia (mll, also known as all 1, htrx, trx1, or hrx) gene that occur with increased frequency in this population. Mll-rearranged cases with a mature B-cell phenotype are rare. The authors describe an infant with mature B-cell lymphoblastic leukemia with an mll rearrangement and L1/L2 cytomorphology and discuss the clinical, genetic, and immunophenotypic features in the context of previously reported cases.

Original languageEnglish
Pages (from-to)672-677
Number of pages6
JournalJournal of Pediatric Hematology/Oncology
Issue number10
StatePublished - Oct 1 2004


  • Lymphoblastic leukemia
  • Surface immunoglobulin
  • mll


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