With the recent advances in our understanding of the function and biology of the lymphatic vascular system, it is clear that the lymphatic system plays an integral role in physiology, and in pathological settings, may contribute to either enhance or repress inflammation and disease progression. Inflammation is central to both acute and chronic rejection in the context of solid organ transplantation, and emerging evidence suggests the lymphatic system plays a key role in shaping outcomes. The goals of this review are to highlight and contextualize the roles of lymphatic vessels and lymphangiogenesis in immunobiology, the impact immunosuppressive therapies have on the lymphatic system and emerging evidence of organ-specific heterogeneity of lymphatic vessels in the context of solid organ transplantation.

Original languageEnglish
Pages (from-to)1992-2000
Number of pages9
JournalAmerican Journal of Transplantation
Issue number8
StatePublished - Aug 1 2020


  • basic (laboratory) research
  • cellular biology
  • immunobiology
  • lymph node
  • lymphocyte biology
  • organ transplantation in general
  • rejection
  • science
  • science
  • tissue injury and repair
  • translational research
  • vascular biology


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