Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)

Stephen L. Lee, Yoel Sadovsky, Alexander H. Swirnoff, Jeffrey A. Polish, Pam Goda, Galina Gavrilina, Jeffrey Milbrandt

Research output: Contribution to journalArticle

419 Scopus citations

Abstract

The immediate-early transcription factor NGFI-A (also called Egr-1, zif/268, or Krox-24) is thought to couple extracellular signals to changes in gene expression. Although activins and inhibins regulate follicle-stimulating hormone (FSH) synthesis, no factor has been identified that exclusively regulates luteinizing hormone (LH) synthesis. An analysis of NGFI-A- deficient mice derived from embryonic stem cells demonstrated female infertility that was secondary to LH-β deficiency. Ovariectomy led to increased amounts of FSH-β, but not LH-β messenger RNA, which suggested a pituitary defect. A conserved, canonical NGFI-A site in the LH-β promoter was required for synergistic activation by NGFI-A and steroidogenic factor-1 (SF-1). NGFI-A apparently influences female reproductive capacity through its regulation of LH-β transcription.

Original languageEnglish
Pages (from-to)1219-1221
Number of pages3
JournalScience
Volume273
Issue number5279
DOIs
StatePublished - Jan 1 1996

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