Lung transplantation in infants and toddlers from 1990 to 2004 at St. Louis children's hospital

A. Elizur, A. Faro, C. B. Huddleston, S. K. Gandhi, D. White, C. A. Kuklinski, S. C. Sweet

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

In a retrospective, single-center cohort study, outcomes of infants and toddlers undergoing lung transplant at St. Louis Children's Hospital between 1990 and 2004 were compared to older children. Patients with cystic fibrosis (exclusively older children) and those who underwent heart-lung, liver-lung, single lung or a second transplantation were excluded from comparisons. One hundred nine lung transplants were compared. Thirty-six were in infants <1 year old, 26 in toddlers 1-3 years old and 47 in children >3 years old. Graft survival was similar for infants and toddlers (p = 0.35 and p = 0.3, respectively) compared to children over 3 years old at 1 and 3 years after transplant. Significantly more infants (p < 0.0001 and p = 0.003) and toddlers (p = 0.002 and p = 0.03) were free from acute rejection and bronchiolitis obliterans compared to older patients. While most infants and toddlers had only minimal lung function impairment, and achieved normal to mildly delayed developmental scores, somatic growth remained depressed 5 years after transplant. Lung transplantation in infants and young children carries similar survival rates to older children and adults. Further insights into the unique immunologic aspects of this group of patients may elucidate strategies to prevent acute and chronic rejection in all age groups.

Original languageEnglish
Pages (from-to)719-726
Number of pages8
JournalAmerican Journal of Transplantation
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2009

Keywords

  • Acute rejection
  • Bronchiolitis obliterans
  • Graft survival
  • Growth after transplant
  • Infants
  • Lung transplantation

Fingerprint Dive into the research topics of 'Lung transplantation in infants and toddlers from 1990 to 2004 at St. Louis children's hospital'. Together they form a unique fingerprint.

  • Cite this