Lung transplantation in children and young adults with cardiovascular disease

Nancy D. Bridges, George B. Mallory, Charles B. Huddleston, Charles E. Canter, Stuart C. Sweet, Thomas L. Spray

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Single or bilateral lung transplantation was performed in 20 patients with pulmonary hypertension or an inadequate pulmonary vascular bed; all but 1 had congenital heart disease. The average age was 6.3 years (range, 3 months to 23.9 years). All were in New York Heart Association class IV, and 6 were hospitalized and receiving intensive support before transplantation. Hospital survival was 70% (14/20), with three additional deaths at 7, 11, and 27 months. A prior thoracic operation contributed to three of six hospital deaths from hemorrhage. All late deaths were due directly or indirectly to obliterative bronchiolitis. At a mean follow-up of 19 months (range, 2 to 48 months), 10 of 11 survivors are in New York Heart Association class I. Survival after hospital discharge and incidence of obliterative bronchiolitis are similar in a contemporary group of 41 patients of comparable age who underwent lung transplantation for pulmonary disease (p = not significant). Single or bilateral lung transplantation is an acceptable therapy for children with pulmonary hypertension, congenital heart disease, or both. Further investigation in the areas of pretransplantation survival, operative risk factors, and long-term outcome of single-lung recipients and recipients with hemodynamically insignificant intracardiac lesions are needed to develop optimal decision-making strategies for these patients.

Original languageEnglish
Pages (from-to)813-821
Number of pages9
JournalAnnals of Thoracic Surgery
Issue number4
StatePublished - 1995


Dive into the research topics of 'Lung transplantation in children and young adults with cardiovascular disease'. Together they form a unique fingerprint.

Cite this