Lung transplantation and bronchiolitis obliterans an evolution in understanding

Brice W. McKane, E. P. Trulock, G. A. Patterson, T. Mohanakumar

Research output: Contribution to journalArticle

12 Scopus citations


Major advancements in the field of lung transplantation have occurred over the past thirty-five years. Despite these advancements, limitations in our ability to obtain sufficient numbers of organs and in our comprehension of the problems associated with the procedure persist. The purpose of this article is to review the current understanding of both the surgical procedure and its most unfortunate complication, bronchiolitis obliterans. Even now, after over three decades of experience, this complication remains the most significant cause of morbidity and mortality following lung transplantation. This article is not meant to be an exhaustive review, and certainly there are important topics not covered herein. We have focused the discussion on ongoing studies, which attempt to understand bronchiolitis obliterans at both the clinical as well as the immunopathological level.

Original languageEnglish
Pages (from-to)177-190
Number of pages14
JournalImmunologic Research
Issue number2
StatePublished - Oct 6 2001


  • Bronchiolitis Obliterans
  • Immunopathogenesis
  • Lung Transplantation
  • Obliterative Bronchiolitis
  • Syndrome

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