@article{f3ffa80d3bc5470aa04647f14ea4a56a,
title = "Lung Quality and Utilization in Controlled Donation after Circulatory Determination of Death Within the United States",
abstract = "Although controlled donation after circulatory determination of death (cDCDD) could increase the supply of donor lungs within the United States, the yield of lungs from cDCDD donors remains low compared with donation after neurologic determination of death (DNDD). To explore the reason for low lung yield from cDCDD donors, Scientific Registry of Transplant Recipient data were used to assess the impact of donor lung quality on cDCDD lung utilization by fitting a logistic regression model. The relationship between center volume and cDCDD use was assessed, and the distance between center and donor hospital was calculated by cDCDD status. Recipient survival was compared using a multivariable Cox regression model. Lung utilization was 2.1% for cDCDD donors and 21.4% for DNDD donors. Being a cDCDD donor decreased lung donation (adjusted odds ratio 0.101, 95% confidence interval [CI] 0.085-0.120). A minority of centers have performed cDCDD transplant, with higher volume centers generally performing more cDCDD transplants. There was no difference in center-to-donor distance or recipient survival (adjusted hazard ratio 1.03, 95% CI 0.78-1.37) between cDCDD and DNDD transplants. cDCDD lungs are underutilized compared with DNDD lungs after adjusting for lung quality. Increasing transplant center expertise and commitment to cDCDD lung procurement is needed to improve utilization.",
author = "Mooney, {J. J.} and H. Hedlin and Mohabir, {P. K.} and R. Vazquez and J. Nguyen and R. Ha and P. Chiu and K. Patel and Zamora, {M. R.} and D. Weill and Nicolls, {M. R.} and Dhillon, {G. S.}",
note = "Funding Information: We appreciate the generous provision of information on the rate of aborted cDCDD procurement attempts by the following OPOs: Donor Network West, Sierra Donor Network, New England Organ Bank, Donor Alliance, Intermountain Donor Services, LifeGift Organ Donation Center, and the Center for Organ Recovery and Education and their donors and donor families. We appreciate the assistance of Director of Business and Transplant Outreach Operations Kim Standridge at Stanford Health Care in providing information on the cost of aborted lung procurements. This work was conducted with support from a KL2 Mentored Career Development Award of the Stanford Clinical and Translational Science Award to Spectrum (NIH KL2 TR 001083 [J.J.M.], HL095686 [M.R.N.]), the Ranzetta Family Foundation, and the Hearst Foundation. The Scientific Registry of Transplant Recipients (SRTR) data reported were supplied by the Minneapolis Medical Research Foundation as the contractor for the SRTR. The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy of or interpretation by the SRTR or the U.S. government. Publisher Copyright: {\textcopyright} 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.",
year = "2016",
month = apr,
day = "1",
doi = "10.1111/ajt.13599",
language = "English",
volume = "16",
pages = "1207--1215",
journal = "American Journal of Transplantation",
issn = "1600-6135",
number = "4",
}