TY - JOUR
T1 - Lung connective tissue
AU - Clark, J. G.
AU - Kuhn, C.
AU - McDonald, J. A.
AU - Mecham, R. P.
PY - 1983
Y1 - 1983
N2 - Connective tissue plays a central role in the structure of lung, an organ in which structure and physiologic performance are inseparable. Recognition that many diseases of lung involve damage and remodeling of connective tissue has prompted efforts to define the precise composition of lung connective tissue and to identify factors that affect its synthesis, deposition, and degradation. As a consequence of these endeavors, studies of lung connective tissue have come to encompass information about nonstructural extracellular matrix macromolecules and the biology of inflammatory cells, as well as parenchymal lung cells and structural matrix components. As information has been integrated from these diverse areas, important insights into lung connective tissue remodeling have been acquired. In the future, further progress in understanding the contribution of connective tissue to lung structure and function in health and disease can be expected from this broader approach.
AB - Connective tissue plays a central role in the structure of lung, an organ in which structure and physiologic performance are inseparable. Recognition that many diseases of lung involve damage and remodeling of connective tissue has prompted efforts to define the precise composition of lung connective tissue and to identify factors that affect its synthesis, deposition, and degradation. As a consequence of these endeavors, studies of lung connective tissue have come to encompass information about nonstructural extracellular matrix macromolecules and the biology of inflammatory cells, as well as parenchymal lung cells and structural matrix components. As information has been integrated from these diverse areas, important insights into lung connective tissue remodeling have been acquired. In the future, further progress in understanding the contribution of connective tissue to lung structure and function in health and disease can be expected from this broader approach.
UR - http://www.scopus.com/inward/record.url?scp=0020973413&partnerID=8YFLogxK
U2 - 10.1016/b978-0-12-363710-9.50011-3
DO - 10.1016/b978-0-12-363710-9.50011-3
M3 - Article
C2 - 6358098
AN - SCOPUS:0020973413
VL - VOL.10
SP - 249
EP - 331
JO - International Review of Connective Tissue Research
JF - International Review of Connective Tissue Research
ER -