Lung and heart-lung transplantation: Overview of results

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

During the last decade, activity in lung transplantation increased rapidly to a plateau of approximately 900 transplants per year in the United States, and it is unlikely to increase further unless the supply of useable donor organs can be expanded. However, the demand for lung transplantation has continued to rise, and the median waiting time for lung transplantation in the United States is approaching 2 years. The main indications for lung transplantation have been chronic obstructive pulmonary disease, α1-antitrypsin deficiency emphysema, cystic fibrosis, idiopathic pulmonary fibrosis, primary pulmonary hypertension, and Eisenmenger's syndrome. Overall, survival after lung transplantation has been good, with 1-, 3-, and 5-year survival rates of 75, 58, and 44%, respectively, and the results have been improving. Chronic rejection and infection have been the main causes of medium-term mortality, and the high prevalence of chronic rejection remains a barrier to better outcomes. Quality of life has been enhanced by lung transplantation, but the posttransplantation immunosuppressive regimen has been associated with considerable morbidity.

Original languageEnglish
Pages (from-to)479-488
Number of pages10
JournalSeminars in Respiratory and Critical Care Medicine
Volume22
Issue number5
DOIs
StatePublished - Jan 1 2001

Keywords

  • Lung transplant activity
  • Lung transplant outcomes
  • Lung transplantation
  • Organ allocation

Fingerprint Dive into the research topics of 'Lung and heart-lung transplantation: Overview of results'. Together they form a unique fingerprint.

  • Cite this