Lung Allograft Rejection

Deborah J. Levine; Ramsey R. Hachem

doi:10.1016/j.thorsurg.2021.12.003

Lung Allograft Rejection

Deborah J. Levine
, Ramsey R. Hachem

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Rejection is a major complication following lung transplantation. Acute cellular rejection (ACR), and antibody-mediated rejection (AMR) are risk factors for the subsequent development of chronic lung allograft dysfunction and worse outcomes after transplantation. Although ACR has well-defined histopathologic diagnostic criteria and grading, the diagnosis of AMR requires a multidisciplinary diagnostic approach. This article reviews the identification, clinical and pathologic features of, and therapeutic options for ACR and AMR.

Original language	English
Pages (from-to)	221-229
Number of pages	9
Journal	Thoracic surgery clinics
Volume	32
Issue number	2
DOIs	https://doi.org/10.1016/j.thorsurg.2021.12.003
State	Published - May 1 2022

Keywords

Acute cellular rejection
Antibody-mediated rejection
Donor-specific antibodies
Lung transplantation

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10.1016/j.thorsurg.2021.12.003

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title = "Lung Allograft Rejection",

abstract = "Rejection is a major complication following lung transplantation. Acute cellular rejection (ACR), and antibody-mediated rejection (AMR) are risk factors for the subsequent development of chronic lung allograft dysfunction and worse outcomes after transplantation. Although ACR has well-defined histopathologic diagnostic criteria and grading, the diagnosis of AMR requires a multidisciplinary diagnostic approach. This article reviews the identification, clinical and pathologic features of, and therapeutic options for ACR and AMR.",

keywords = "Acute cellular rejection, Antibody-mediated rejection, Donor-specific antibodies, Lung transplantation",

author = "Levine, \{Deborah J.\} and Hachem, \{Ramsey R.\}",

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doi = "10.1016/j.thorsurg.2021.12.003",

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T1 - Lung Allograft Rejection

AU - Levine, Deborah J.

AU - Hachem, Ramsey R.

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Rejection is a major complication following lung transplantation. Acute cellular rejection (ACR), and antibody-mediated rejection (AMR) are risk factors for the subsequent development of chronic lung allograft dysfunction and worse outcomes after transplantation. Although ACR has well-defined histopathologic diagnostic criteria and grading, the diagnosis of AMR requires a multidisciplinary diagnostic approach. This article reviews the identification, clinical and pathologic features of, and therapeutic options for ACR and AMR.

AB - Rejection is a major complication following lung transplantation. Acute cellular rejection (ACR), and antibody-mediated rejection (AMR) are risk factors for the subsequent development of chronic lung allograft dysfunction and worse outcomes after transplantation. Although ACR has well-defined histopathologic diagnostic criteria and grading, the diagnosis of AMR requires a multidisciplinary diagnostic approach. This article reviews the identification, clinical and pathologic features of, and therapeutic options for ACR and AMR.

KW - Acute cellular rejection

KW - Antibody-mediated rejection

KW - Donor-specific antibodies

KW - Lung transplantation

UR - https://www.scopus.com/pages/publications/85129347792

U2 - 10.1016/j.thorsurg.2021.12.003

DO - 10.1016/j.thorsurg.2021.12.003

M3 - Review article

C2 - 35512940

AN - SCOPUS:85129347792

SN - 1547-4127

VL - 32

SP - 221

EP - 229

JO - Thoracic surgery clinics

JF - Thoracic surgery clinics

IS - 2

ER -

Lung Allograft Rejection

Abstract

Keywords

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