Lung Allograft Rejection

Deborah J. Levine, Ramsey R. Hachem

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Rejection is a major complication following lung transplantation. Acute cellular rejection (ACR), and antibody-mediated rejection (AMR) are risk factors for the subsequent development of chronic lung allograft dysfunction and worse outcomes after transplantation. Although ACR has well-defined histopathologic diagnostic criteria and grading, the diagnosis of AMR requires a multidisciplinary diagnostic approach. This article reviews the identification, clinical and pathologic features of, and therapeutic options for ACR and AMR.

Original languageEnglish
Pages (from-to)221-229
Number of pages9
JournalThoracic surgery clinics
Issue number2
StatePublished - May 1 2022


  • Acute cellular rejection
  • Antibody-mediated rejection
  • Donor-specific antibodies
  • Lung transplantation


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