TY - JOUR
T1 - Lung Allograft Rejection
AU - Levine, Deborah J.
AU - Hachem, Ramsey R.
N1 - Publisher Copyright:
Copyright © 2021 Elsevier Inc. All rights reserved.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Rejection is a major complication following lung transplantation. Acute cellular rejection (ACR), and antibody-mediated rejection (AMR) are risk factors for the subsequent development of chronic lung allograft dysfunction and worse outcomes after transplantation. Although ACR has well-defined histopathologic diagnostic criteria and grading, the diagnosis of AMR requires a multidisciplinary diagnostic approach. This article reviews the identification, clinical and pathologic features of, and therapeutic options for ACR and AMR.
AB - Rejection is a major complication following lung transplantation. Acute cellular rejection (ACR), and antibody-mediated rejection (AMR) are risk factors for the subsequent development of chronic lung allograft dysfunction and worse outcomes after transplantation. Although ACR has well-defined histopathologic diagnostic criteria and grading, the diagnosis of AMR requires a multidisciplinary diagnostic approach. This article reviews the identification, clinical and pathologic features of, and therapeutic options for ACR and AMR.
KW - Acute cellular rejection
KW - Antibody-mediated rejection
KW - Donor-specific antibodies
KW - Lung transplantation
UR - http://www.scopus.com/inward/record.url?scp=85129347792&partnerID=8YFLogxK
U2 - 10.1016/j.thorsurg.2021.12.003
DO - 10.1016/j.thorsurg.2021.12.003
M3 - Review article
C2 - 35512940
AN - SCOPUS:85129347792
SN - 1547-4127
VL - 32
SP - 221
EP - 229
JO - Thoracic Surgery Clinics
JF - Thoracic Surgery Clinics
IS - 2
ER -