TY - JOUR
T1 - LR1
T2 - A candidate RNA virus of Leishmania
AU - Tarr, P. I.
AU - Aline, R. F.
AU - Smiley, B. L.
AU - Scholler, J.
AU - Keithly, J.
AU - Stuart, K.
PY - 1988
Y1 - 1988
N2 - Although viruses are important biological agents and useful molecular tools, little is known about the viruses of parasites. We report here the discovery of a candidate for an RNA virus in a kinetoplastid parasite. This potential virus, which we term LR1, is present in the promastigote form of the human pathogen Leishmania braziliensis guyanensis CUMC1-1A but not in 11 other stocks of Leishmania that were examined nor in Trypanosoma brucei. The candidate viral RNA has a size of ~ 6000 nucleotides, is single-stranded, and is largely, if not exclusively, located in the cytoplasm. No homologous LR1 sequences are detected in genomic DNA. The candidate viral RNA is associated with a spherical particle 32 nm in diameter that has a sedimentation coefficient of ~ 130 S. There is as yet no evident effect of this potential virus on parasite physiology or the disease caused by the parasite.
AB - Although viruses are important biological agents and useful molecular tools, little is known about the viruses of parasites. We report here the discovery of a candidate for an RNA virus in a kinetoplastid parasite. This potential virus, which we term LR1, is present in the promastigote form of the human pathogen Leishmania braziliensis guyanensis CUMC1-1A but not in 11 other stocks of Leishmania that were examined nor in Trypanosoma brucei. The candidate viral RNA has a size of ~ 6000 nucleotides, is single-stranded, and is largely, if not exclusively, located in the cytoplasm. No homologous LR1 sequences are detected in genomic DNA. The candidate viral RNA is associated with a spherical particle 32 nm in diameter that has a sedimentation coefficient of ~ 130 S. There is as yet no evident effect of this potential virus on parasite physiology or the disease caused by the parasite.
UR - https://www.scopus.com/pages/publications/0024266522
U2 - 10.1073/pnas.85.24.9572
DO - 10.1073/pnas.85.24.9572
M3 - Article
C2 - 3200841
AN - SCOPUS:0024266522
SN - 0027-8424
VL - 85
SP - 9572
EP - 9275
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 24
ER -