LR1: A candidate RNA virus of Leishmania

P. I. Tarr, R. F. Aline, B. L. Smiley, J. Scholler, J. Keithly, K. Stuart

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

Although viruses are important biological agents and useful molecular tools, little is known about the viruses of parasites. We report here the discovery of a candidate for an RNA virus in a kinetoplastid parasite. This potential virus, which we term LR1, is present in the promastigote form of the human pathogen Leishmania braziliensis guyanensis CUMC1-1A but not in 11 other stocks of Leishmania that were examined nor in Trypanosoma brucei. The candidate viral RNA has a size of ~ 6000 nucleotides, is single-stranded, and is largely, if not exclusively, located in the cytoplasm. No homologous LR1 sequences are detected in genomic DNA. The candidate viral RNA is associated with a spherical particle 32 nm in diameter that has a sedimentation coefficient of ~ 130 S. There is as yet no evident effect of this potential virus on parasite physiology or the disease caused by the parasite.

Original languageEnglish
Pages (from-to)9572-9275
Number of pages298
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number24
StatePublished - Dec 1 1988
Externally publishedYes

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    Tarr, P. I., Aline, R. F., Smiley, B. L., Scholler, J., Keithly, J., & Stuart, K. (1988). LR1: A candidate RNA virus of Leishmania. Proceedings of the National Academy of Sciences of the United States of America, 85(24), 9572-9275.