Lowering Low-Density Lipoprotein Cholesterol: Statins, Ezetimibe, Bile Acid Sequestrants, and Combinations: Comparative Efficacy and Safety

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Abstract

Statins, ezetimibe, and bile acid-binding resins can be used individually or in combination for lowering low-density lipoprotein cholesterol (LDL-C) levels. Statins are the most potent drugs for lowering LDL-C and are well tolerated in most patients. The addition of a bile acid sequestrant or ezetimibe to a statin produces additional LDL-C reduction allowing many patients to reach LDL-C targets. This article discusses the efficacy and safety of available statins, bile acid sequestrants, and ezetimibe in the treatment of hyperlipidemia.

Original languageEnglish
Pages (from-to)79-97
Number of pages19
JournalEndocrinology and Metabolism Clinics of North America
Volume38
Issue number1
DOIs
StatePublished - Mar 2009

Keywords

  • Bile acid sequestrants
  • Efficacy
  • Ezetimibe
  • LDL-C
  • Safety
  • Statins

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