Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration

David Croteau, Brookie M. Best, Scott Letendre, Steven S. Rossi, Ronald J. Ellis, David B. Clifford, Ann C. Collier, Benjamin B. Gelman, Justin C. McArthur, John Allen McCutchan, Susan Morgello, Igor Grant

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

To measure maraviroc total cerebrospinal fluid (CSF) concentrations and compare them with total and unbound plasma concentrations. Total maraviroc was measured by reverse-phase high-performance liquid chromatography with tandem mass spectrometry, whereas ultrafiltration was used for unbound maraviroc. Maraviroc was detected in all nine CSF/plasma pairs with a median CSF total concentration of 2.4ng/ml. CSF concentrations exceeded the 50% inhibitory concentration of wild-type CC chemokine receptor 5-tropic HIV-1 in all specimens. CSF concentrations are lower than expected based on plasma concentrations and physicochemical characteristics. Unbound maraviroc plasma concentrations may be informative in estimating concentrations in CSF.

Original languageEnglish
Pages (from-to)890-893
Number of pages4
JournalAIDS
Volume26
Issue number7
DOIs
StatePublished - Apr 24 2012

Fingerprint Dive into the research topics of 'Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration'. Together they form a unique fingerprint.

  • Cite this

    Croteau, D., Best, B. M., Letendre, S., Rossi, S. S., Ellis, R. J., Clifford, D. B., Collier, A. C., Gelman, B. B., McArthur, J. C., McCutchan, J. A., Morgello, S., & Grant, I. (2012). Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration. AIDS, 26(7), 890-893. https://doi.org/10.1097/QAD.0b013e328351f627