Lower Respiratory Tract Myeloid Cells Harbor SARS-Cov-2 and Display an Inflammatory Phenotype

William G. Bain; Hernán F. Peñaloza; Mark S. Ladinsky; Rick van der Geest; Mara Sullivan; Mark Ross; Georgios D. Kitsios; Barbara A. Methé; Bryan J. McVerry; Alison Morris; Alan M. Watson; Simon C. Watkins; Claudette M. St Croix; Donna B. Stolz; Pamela J. Bjorkman; Janet S. Lee

doi:10.1016/j.chest.2020.10.083

Lower Respiratory Tract Myeloid Cells Harbor SARS-Cov-2 and Display an Inflammatory Phenotype

William G. Bain
, Hernán F. Peñaloza
, Mark S. Ladinsky
, Rick van der Geest
, Mara Sullivan
, Mark Ross
, Georgios D. Kitsios
, Barbara A. Methé
, Bryan J. McVerry
, Alison Morris
, Alan M. Watson
, Simon C. Watkins
, Claudette M. St Croix
, Donna B. Stolz
, Pamela J. Bjorkman
, Janet S. Lee

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	963-966
Number of pages	4
Journal	CHEST
Volume	159
Issue number	3
DOIs	https://doi.org/10.1016/j.chest.2020.10.083
State	Published - Mar 2021

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10.1016/j.chest.2020.10.083

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Bain, W. G., Peñaloza, H. F., Ladinsky, M. S., van der Geest, R., Sullivan, M., Ross, M., Kitsios, G. D., Methé, B. A., McVerry, B. J., Morris, A., Watson, A. M., Watkins, S. C., St Croix, C. M., Stolz, D. B., Bjorkman, P. J., & Lee, J. S. (2021). Lower Respiratory Tract Myeloid Cells Harbor SARS-Cov-2 and Display an Inflammatory Phenotype. CHEST, 159(3), 963-966. https://doi.org/10.1016/j.chest.2020.10.083

@article{510a2c089e6a47c8a3fab51bb18a327f,

title = "Lower Respiratory Tract Myeloid Cells Harbor SARS-Cov-2 and Display an Inflammatory Phenotype",

author = "Bain, \{William G.\} and Pe{\~n}aloza, \{Hern{\'a}n F.\} and Ladinsky, \{Mark S.\} and \{van der Geest\}, Rick and Mara Sullivan and Mark Ross and Kitsios, \{Georgios D.\} and Meth{\'e}, \{Barbara A.\} and McVerry, \{Bryan J.\} and Alison Morris and Watson, \{Alan M.\} and Watkins, \{Simon C.\} and \{St Croix\}, \{Claudette M.\} and Stolz, \{Donna B.\} and Bjorkman, \{Pamela J.\} and Lee, \{Janet S.\}",

note = "Funding Information: FUNDING/SUPPORT: This work was supported by Career Development Award Number IK2 BX004886 from the United States Department of Veterans Affairs Biomedical Laboratory R\&D (BLRD) Service (W. Bain); the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Numbers K23 HL129987 (G. Kitsios); P01HL114453 (J. Lee, B. McVerry); and R01 HL136143 , R01 HL142084 , K24 HL143285 (J. Lee) and R21 HL143091 (B. A. Meth{\'e}); and the UPMC Immune Therapy and Transplant Center (A. Morris). Electron and confocal microscopy at the University of Pittsburgh Center for Biologic Imaging was supported by National Institutes of Health Office of the Director awards S10OD010625 and S10OD019973 (S. Watkins). Electron tomography at the California Institute of Technology was supported by a George Mason University Fast Grant (P. Bjorkman), National Institute of Allergy and Infectious Diseases (NIAID) Grant 2 P50 AI150464 (P. Bjorkman). Electron microscopy was performed with a TF-30 electron microscope that is maintained by the California Institute of Technology Kavli Nanoscience Institute. Funding Information: FUNDING/SUPPORT: This work was supported by Career Development Award Number IK2 BX004886 from the United States Department of Veterans Affairs Biomedical Laboratory R\&D (BLRD) Service (W. Bain); the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Numbers K23 HL129987 (G. Kitsios); P01HL114453 (J. Lee, B. McVerry); and R01 HL136143, R01 HL142084, K24 HL143285 (J. Lee) and R21 HL143091 (B. A. Meth?); and the UPMC Immune Therapy and Transplant Center (A. Morris). Electron and confocal microscopy at the University of Pittsburgh Center for Biologic Imaging was supported by National Institutes of Health Office of the Director awards S10OD010625 and S10OD019973 (S. Watkins). Electron tomography at the California Institute of Technology was supported by a George Mason University Fast Grant (P. Bjorkman), National Institute of Allergy and Infectious Diseases (NIAID) Grant 2 P50 AI150464 (P. Bjorkman). Electron microscopy was performed with a TF-30 electron microscope that is maintained by the California Institute of Technology Kavli Nanoscience Institute. FINANCIAL/NONFINANCIAL DISCLOSURES: None declared.",

year = "2021",

month = mar,

doi = "10.1016/j.chest.2020.10.083",

language = "English",

volume = "159",

pages = "963--966",

journal = "CHEST",

issn = "0012-3692",

number = "3",

}

Bain, WG, Peñaloza, HF, Ladinsky, MS, van der Geest, R, Sullivan, M, Ross, M, Kitsios, GD, Methé, BA, McVerry, BJ, Morris, A, Watson, AM, Watkins, SC, St Croix, CM, Stolz, DB, Bjorkman, PJ & Lee, JS 2021, 'Lower Respiratory Tract Myeloid Cells Harbor SARS-Cov-2 and Display an Inflammatory Phenotype', CHEST, vol. 159, no. 3, pp. 963-966. https://doi.org/10.1016/j.chest.2020.10.083

TY - JOUR

T1 - Lower Respiratory Tract Myeloid Cells Harbor SARS-Cov-2 and Display an Inflammatory Phenotype

AU - Bain, William G.

AU - Peñaloza, Hernán F.

AU - Ladinsky, Mark S.

AU - van der Geest, Rick

AU - Sullivan, Mara

AU - Ross, Mark

AU - Kitsios, Georgios D.

AU - Methé, Barbara A.

AU - McVerry, Bryan J.

AU - Morris, Alison

AU - Watson, Alan M.

AU - Watkins, Simon C.

AU - St Croix, Claudette M.

AU - Stolz, Donna B.

AU - Bjorkman, Pamela J.

AU - Lee, Janet S.

N1 - Funding Information: FUNDING/SUPPORT: This work was supported by Career Development Award Number IK2 BX004886 from the United States Department of Veterans Affairs Biomedical Laboratory R&D (BLRD) Service (W. Bain); the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Numbers K23 HL129987 (G. Kitsios); P01HL114453 (J. Lee, B. McVerry); and R01 HL136143 , R01 HL142084 , K24 HL143285 (J. Lee) and R21 HL143091 (B. A. Methé); and the UPMC Immune Therapy and Transplant Center (A. Morris). Electron and confocal microscopy at the University of Pittsburgh Center for Biologic Imaging was supported by National Institutes of Health Office of the Director awards S10OD010625 and S10OD019973 (S. Watkins). Electron tomography at the California Institute of Technology was supported by a George Mason University Fast Grant (P. Bjorkman), National Institute of Allergy and Infectious Diseases (NIAID) Grant 2 P50 AI150464 (P. Bjorkman). Electron microscopy was performed with a TF-30 electron microscope that is maintained by the California Institute of Technology Kavli Nanoscience Institute. Funding Information: FUNDING/SUPPORT: This work was supported by Career Development Award Number IK2 BX004886 from the United States Department of Veterans Affairs Biomedical Laboratory R&D (BLRD) Service (W. Bain); the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Numbers K23 HL129987 (G. Kitsios); P01HL114453 (J. Lee, B. McVerry); and R01 HL136143, R01 HL142084, K24 HL143285 (J. Lee) and R21 HL143091 (B. A. Meth?); and the UPMC Immune Therapy and Transplant Center (A. Morris). Electron and confocal microscopy at the University of Pittsburgh Center for Biologic Imaging was supported by National Institutes of Health Office of the Director awards S10OD010625 and S10OD019973 (S. Watkins). Electron tomography at the California Institute of Technology was supported by a George Mason University Fast Grant (P. Bjorkman), National Institute of Allergy and Infectious Diseases (NIAID) Grant 2 P50 AI150464 (P. Bjorkman). Electron microscopy was performed with a TF-30 electron microscope that is maintained by the California Institute of Technology Kavli Nanoscience Institute. FINANCIAL/NONFINANCIAL DISCLOSURES: None declared.

PY - 2021/3

Y1 - 2021/3

UR - https://www.scopus.com/pages/publications/85101328522

U2 - 10.1016/j.chest.2020.10.083

DO - 10.1016/j.chest.2020.10.083

M3 - Article

C2 - 33217417

AN - SCOPUS:85101328522

SN - 0012-3692

VL - 159

SP - 963

EP - 966

JO - CHEST

JF - CHEST

IS - 3

ER -

Lower Respiratory Tract Myeloid Cells Harbor SARS-Cov-2 and Display an Inflammatory Phenotype

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