@article{7900165a38ff4299883ef022eae06565,
title = "Low-risk human papilloma virus positive oropharyngeal cancer with one positive lymph node: Equivalent outcomes in patients treated with surgery and radiation therapy versus surgery alone",
abstract = "Background: For human papilloma virus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC), management recommendations for patients with a single metastatic lymph node <6 cm in diameter remain nebulous, leading to treatment heterogeneity in this common subgroup of patients. Methods: We utilized the National Cancer Database to perform survival and multivariable analyses of patients with HPV+ OPSCC with one positive lymph node <6 cm and negative surgical margins. Results: We found that 5-year survival is comparable between patients who receive surgery and adjuvant radiation versus surgery alone. In multivariable analyses, we found no significant difference in the hazard ratio of overall survival after adjusting for various potential confounders. Conclusions: These data suggest that patients with margin-negative HPV+ OPSCC with a single positive lymph node <6 cm have comparable survival with or without adjuvant radiation. Future studies exploring outcomes for this specific group in randomized-controlled trials will be critical for further evaluating these initial observations.",
keywords = "HPV, de-escalation, head and neck cancer, oropharyngeal cancer, radiation",
author = "Sample, {Reilly A.} and Wood, {Carey Burton} and Mazul, {Angela L.} and Barrett, {Thomas F.} and Paniello, {Randal C.} and Rich, {Jason T.} and Kang, {Stephen Y.} and Jose Zevallos and Daly, {Mackenzie D.} and Thorstad, {Wade L.} and Chen, {Stephanie Y.} and Patrik Pipkorn and Jackson, {Ryan S.} and Puram, {Sidharth V.}",
note = "Funding Information: National Institutes of Health, Grant/Award Numbers: K08CA237732, TR002344; Doris Duke Fund; American Academy of Otolaryngology – Head and Neck Surgery; Cancer Research Foundation; V Foundation Funding information Funding Information: This work was supported by NIH (NCI K08CA237732), V Foundation V Scholar Award, Cancer Research Foundation Young Investigator Award, American Academy of Otolaryngology – Head and Neck Surgery Bobby Alford Award, and the Doris Duke Fund to Retain Clinician Scientists (Sidharth V. Puram). Research reported in this publication was also supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number TL1 TR002344. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC.",
year = "2021",
month = jun,
doi = "10.1002/hed.26642",
language = "English",
volume = "43",
pages = "1759--1768",
journal = "Head & Neck",
issn = "1043-3074",
number = "6",
}