@inproceedings{6763fbb2f6624c028f3ec6c309017283,
title = "Low-cost disposable point-of-care devices based on porous materials for rapid detection of pathogens",
abstract = "Porous materials such as nitrocellulose, cellulose and glass fiber, when combined with switchable interconnections, support complex sequential chemical processes like sample-to-result chemical detection with minimal supporting equipment, and at extremely low cost. Using such two-dimensional paper networks (2DPNs), we have demonstrated user-friendly chemically-amplified sensitive detection of influenza viruses and proteins derived therefrom; we used both antibodies and capture molecules designed de novo as inexpensive tailored alternatives. By combining 2DPNs with isothermal nucleic acid amplification, we have demonstrated an instrument-free disposable platform that performs rapid sample-to-result detection of pathogens by DNA and RNA at sensitivities rivalling the best instrumented systems.",
keywords = "Diagnostics, Inexpensive, Microfluidics, Paper",
author = "P. Yager and K. Abe and Anderson, {C. E.} and D. Baker and Y. Belousov and J. Bishop and Buser, {J. R.} and Byrnes, {S. A.} and G. Domingo and E. Fu and Gallagher, {R. P.} and Heiniger, {E. K.} and Holstein, {C. A.} and S. Huang and P. Kauffman and Kline, {E. C.} and Ladd, {P. D.} and Lafleur, {L. K.} and Lutz, {B. R.} and W. Mahoney and S. Kumar and N. Scarr and L. Stewart and Strauch, {E. M.} and B. Toley and Vermeulen, {N. M.J.} and X. Zhang",
note = "Funding Information: This work was supported by DARPA DSO/BTO grant number HR0011-11-2-0007 and by NIH NIAID grant RO1 AI096184 to Dr. Paul Yager at the University of Washington with subcontracts to Dr. Janet Englund at Seattle Children's, Dr. Elain Fu at Oregon State University, Dr. David Moore at GE Global Research Center, and Dr. Gonzalo Domingo at PATH. We wish to acknowledge helpful communication with collaborators on this grant at UW, Seattle Children's, PATH and GE Global Research. Funding Information: This work was supported by DARPA DSO/BTO grant number HR0011-11-2-0007 and by NIH NIAID grant RO1 AI096184 to Dr. Paul Yager at the University of Washington with subcontracts to Dr. Janet Englund at Seattle Children's, Dr. Elain Fu at Oregon State University, Dr. David Moore at GE Global Research Center, and Dr. Gonzalo Domingo ta APH. WeTwish to acknowledge helpful communication with collaborators on this grant at UW, Seattle Children{\textquoteright}s, PATH and GE Global Research. Publisher Copyright: {\textcopyright} 17CBMS-0001.; 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 ; Conference date: 22-10-2017 Through 26-10-2017",
year = "2020",
language = "English",
series = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
publisher = "Chemical and Biological Microsystems Society",
pages = "97--100",
booktitle = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
}