TY - JOUR
T1 - Low concentrations of N-methyl-d-aspartate inhibit the induction of long-term potentiation in rat hippocampal slices
AU - Izumi, Yukitoshi
AU - Clifford, David B.
AU - Zorumski, Charles F.
N1 - Funding Information:
This work was supported by NIMH Physician Scientist Award MH00630, Grants AG05681 and MH45493, the McDonnell Center for Studies of Higher Brain Function and the Bantly Foundation. The authors thank Drs. John Olney, Jay Yang, Kunio Kato, Liu Lin Thio and James Reggin for many helpful discussions.
PY - 1992/3/30
Y1 - 1992/3/30
N2 - We have examined the effects of excitatory amino acids on tetanus-induced long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. Agonists acting at N-methyl-d-aspartate (NMDA) receptors, including NMDA, aspartate and glutamate, completely block the development of LTP when administered for 5 min prior to tetanic stimulation. Additionally, and unlike the NMDA receptor antagonist 2-amino-5-phosphonovalerate (APV), NMDA blocks LTP when administered for 5 min immediately following the electrical tetanus. The effective concentrations of NMDA are subthreshold for depolarizing CA1 neurons. These results indicate that under certain conditions NMDA receptor activation prevents CA1 LTP.
AB - We have examined the effects of excitatory amino acids on tetanus-induced long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. Agonists acting at N-methyl-d-aspartate (NMDA) receptors, including NMDA, aspartate and glutamate, completely block the development of LTP when administered for 5 min prior to tetanic stimulation. Additionally, and unlike the NMDA receptor antagonist 2-amino-5-phosphonovalerate (APV), NMDA blocks LTP when administered for 5 min immediately following the electrical tetanus. The effective concentrations of NMDA are subthreshold for depolarizing CA1 neurons. These results indicate that under certain conditions NMDA receptor activation prevents CA1 LTP.
KW - Aspartate
KW - Glutamate
KW - Hippocampus
KW - Long-term potentiation
KW - N-Methyl-d-aspartate
UR - http://www.scopus.com/inward/record.url?scp=0026503093&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(92)90414-3
DO - 10.1016/0304-3940(92)90414-3
M3 - Article
C2 - 1350078
AN - SCOPUS:0026503093
SN - 0304-3940
VL - 137
SP - 245
EP - 248
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -