Low concentrations of N-methyl-d-aspartate inhibit the induction of long-term potentiation in rat hippocampal slices

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Abstract

We have examined the effects of excitatory amino acids on tetanus-induced long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. Agonists acting at N-methyl-d-aspartate (NMDA) receptors, including NMDA, aspartate and glutamate, completely block the development of LTP when administered for 5 min prior to tetanic stimulation. Additionally, and unlike the NMDA receptor antagonist 2-amino-5-phosphonovalerate (APV), NMDA blocks LTP when administered for 5 min immediately following the electrical tetanus. The effective concentrations of NMDA are subthreshold for depolarizing CA1 neurons. These results indicate that under certain conditions NMDA receptor activation prevents CA1 LTP.

Original languageEnglish
Pages (from-to)245-248
Number of pages4
JournalNeuroscience Letters
Volume137
Issue number2
DOIs
StatePublished - Mar 30 1992

Keywords

  • Aspartate
  • Glutamate
  • Hippocampus
  • Long-term potentiation
  • N-Methyl-d-aspartate

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