Lost in transdifferentiation

Mark H. Hoofnagle; Brian R. Wamhoff; Gary K. Owens

doi:10.1172/JCI21761

Lost in transdifferentiation

Mark H. Hoofnagle, Brian R. Wamhoff, Gary K. Owens

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

What are the true origins of the smooth muscle cells (SMCs) present in the intimal lesions of transplant arteriosclerosis? A new study in the JCI shows that Sca-1⁺ cells purified from the mouse aortic root can migrate through an irradiated vein graft to the neointima of the vessel and transdifferentiate to express the early SMC differentiation marker gene SM22 (see the related article beginning on page 1258). Do Sca-1⁺ cells transdifferentiate into SMC-like cells, or is activation of SMC marker genes a consequence of fusion of these cells with preexisting SMCs, a possibility raised by results of studies of adult stem cells in animal models of liver regeneration (see the related article beginning on page 1266)? Or could this be bona fide transdifferentiation that recapitulates the pathologic processes in humans?

Original language	English
Pages (from-to)	1249-1251
Number of pages	3
Journal	Journal of Clinical Investigation
Volume	113
Issue number	9
DOIs	https://doi.org/10.1172/JCI21761
State	Published - May 2004

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title = "Lost in transdifferentiation",

abstract = "What are the true origins of the smooth muscle cells (SMCs) present in the intimal lesions of transplant arteriosclerosis? A new study in the JCI shows that Sca-1+ cells purified from the mouse aortic root can migrate through an irradiated vein graft to the neointima of the vessel and transdifferentiate to express the early SMC differentiation marker gene SM22 (see the related article beginning on page 1258). Do Sca-1+ cells transdifferentiate into SMC-like cells, or is activation of SMC marker genes a consequence of fusion of these cells with preexisting SMCs, a possibility raised by results of studies of adult stem cells in animal models of liver regeneration (see the related article beginning on page 1266)? Or could this be bona fide transdifferentiation that recapitulates the pathologic processes in humans?",

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AU - Hoofnagle, Mark H.

AU - Wamhoff, Brian R.

AU - Owens, Gary K.

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N2 - What are the true origins of the smooth muscle cells (SMCs) present in the intimal lesions of transplant arteriosclerosis? A new study in the JCI shows that Sca-1+ cells purified from the mouse aortic root can migrate through an irradiated vein graft to the neointima of the vessel and transdifferentiate to express the early SMC differentiation marker gene SM22 (see the related article beginning on page 1258). Do Sca-1+ cells transdifferentiate into SMC-like cells, or is activation of SMC marker genes a consequence of fusion of these cells with preexisting SMCs, a possibility raised by results of studies of adult stem cells in animal models of liver regeneration (see the related article beginning on page 1266)? Or could this be bona fide transdifferentiation that recapitulates the pathologic processes in humans?

AB - What are the true origins of the smooth muscle cells (SMCs) present in the intimal lesions of transplant arteriosclerosis? A new study in the JCI shows that Sca-1+ cells purified from the mouse aortic root can migrate through an irradiated vein graft to the neointima of the vessel and transdifferentiate to express the early SMC differentiation marker gene SM22 (see the related article beginning on page 1258). Do Sca-1+ cells transdifferentiate into SMC-like cells, or is activation of SMC marker genes a consequence of fusion of these cells with preexisting SMCs, a possibility raised by results of studies of adult stem cells in animal models of liver regeneration (see the related article beginning on page 1266)? Or could this be bona fide transdifferentiation that recapitulates the pathologic processes in humans?

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DO - 10.1172/JCI21761

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SN - 0021-9738

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Lost in transdifferentiation

Abstract

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