Loss of sex discrimination and male-male aggression in mice deficient for TRP2

Lisa Stowers, Timothy E. Holy, Markus Meister, Catherine Dulac, Georgy Koentges

Research output: Contribution to journalArticlepeer-review

652 Scopus citations

Abstract

The mouse vomeronasal organ (VNO) is thought to mediate social behaviors and neuroendocrine changes elicited by pheromonal cues. The molecular mechanisms underlying the sensory response to pheromones and the behavioral repertoire induced through the VNO are not fully characterized. Using the tools of mouse genetics and multielectrode recording, we demonstrate that the sensory activation of VNO neurons requires TRP2, a putative ion channel of the transient receptor potential family that is expressed exclusively in these neurons. Moreover, we show that male mice deficient in TRP2 expression fail to display male-male aggression, and they initiate sexual and courtship behaviors toward both males and females. Our study suggests that, in the mouse, sensory activation of the VNO is essential for sex discrimination of conspecifics and thus ensures gender-specific behavior.

Original languageEnglish
Pages (from-to)1493-1500
Number of pages8
JournalScience
Volume295
Issue number5559
DOIs
StatePublished - Feb 22 2002

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