@article{35f700cad9104861b3e76f17fac6a19c,
title = "Loss of neuronal cell cycle control as a mechanism of neurodegeneration in the presenilin-1 alzheimer's disease brain",
abstract = "Presenilin-1 (PS1) is a component of the β-catenin degradation machinery, and PS1 mutations linked to familial Alzheimer's disease (FAD) represent a loss of this function, leading, in non-neuronal cells, to accumulation of cyclin D1, aberrant cell cycle activation and hyperproliferation. In post-mitotic neurons, cell cycle activation is thought to be abortive and initiate apoptosis, thus contributing to AD pathogenesis. Consequently, we tested here the hypothesis that, in the PS1 FAD brain, cyclin D1 accumulation may occur and lead to neuronal apoptosis secondary to an abortive entry into the cell cycle.",
keywords = "Alzheimer's disease, Apoptosis, Cell cycle, Presenilin, β-catenin",
author = "Bilal Malik and Antonio Currais and Ana Andres and Christopher Towlson and Didier Pitsi and Ana Nunes and Michael Niblock and Jonathan Cooper and Tibor Hortob{\'a}gyi and Salvador Soriano",
note = "Funding Information: 71, male). AD cases {\textcopyright}2008 LANDES BIOSCIENCEFor immunohistochemistry analysis, 7 μm microtome brain autopsy samples; Dr Brian Sopher for the use of presenilin-1 (n = 5, ages 55, female; 86, male; 68, female; 40, male; Council (G9626876) for the use of familial Alzheimer{\textquoteright}s disease sections were cut from paraformaldehyde-fixed paraffin-embedded KIM146V mice; Dr Frank Hirth for his insightful discussion of this human temporal lobe containing the hippocampal formation and manuscript; Mrs Mavis Kibble for her expert technical help with the mounted on glass slides coated with 3-aminopropyltriethoxysilane immunohistochemistry experiments on human samples. (APES). Sections were dewaxed by xylene, rehydrated in graded alco-This work was funded by the Alzheimer{\textquoteright}s Association, USA hols, and endogenous peroxydase activity was blocked by H2O2 in (IIRG-02-3892 to SS) and Alzheimer{\textquoteright}s Research Trust, UK (EG methanol. Standard antigen retrieval treatment was then carried out 2003B to SS).",
year = "2008",
month = mar,
day = "1",
doi = "10.4161/cc.7.5.5427",
language = "English",
volume = "7",
pages = "637--646",
journal = "Cell Cycle",
issn = "1538-4101",
number = "5",
}