Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas

David H. Gutmann, Michael J. Giordano, Amanda S. Fishback, Abhijit Guha

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

Neurofibromatosis 2 (NF2) is an inherited disorder in which affected individuals develop schwannomas and meningiomas. NF2 is mapped to chromosome 22q in a region where frequent loss of heterozygosity also occurs in sporadic meningiomas, ependymomas, and schwannomas. Using NF2 protein (merlin or schwannomin)-specific antibodies, 11 of 14 sporadic schwannomas, three of eight sporadic ependymomas, and 16 of 19 sporadic meningiomas demonstrated significantly reduced or absent merlin expression, suggesting that NF2 may be involved in the pathogenesis of these sporadic tumors.

Original languageEnglish
Pages (from-to)267-270
Number of pages4
JournalNeurology
Volume49
Issue number1
DOIs
StatePublished - Jul 1997

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