Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells

Keyphrases

• Loss Function 100%
• Endoplasmic Reticulum Stress (ER stress) 100%
• Inflammation 100%
• Pancreatic β-cells 100%
• Wolfram Syndrome 100%
• WFS1 100%
• Pancreatic Cells 66%
• Diabetes 50%
• Cell Death 50%
• Unfolded Protein Response 33%
• Whole-body 16%
• Knock-in Mouse Model 16%
• Gene Expression 16%
• Endoplasmic Reticulum 16%
• Cell Inflammation 16%
• Dysregulation 16%
• Transmembrane Protein 16%
• Insulin Secretion 16%
• Type 1 Diabetes Mellitus (T1DM) 16%
• Pathogenic Variants 16%
• Pancreatic Islets 16%
• Cell Dysfunction 16%
• Hearing Impairment 16%
• Progressive Neurodegeneration 16%
• High Glucose 16%
• M1 Macrophages 16%
• Inflammatory Chemokines 16%
• Putative Drug Targets 16%
• Rare Genetic Disease 16%
• Juvenile-onset Diabetes 16%
• Diabetes Insipidus 16%
• Optic Nerve Atrophy 16%
• IRE1 Pathway 16%
• Insulin Production 16%
• Macrophage Infiltration 16%
• Apoptotic Cascade 16%
• WFS1 Gene 16%
• Endoplasmic Reticulum Calcium 16%
• Calcium Depletion 16%
• Anti-inflammatory Response 16%
• Calpain Activity 16%
• Hypervascularization 16%
• PERK Pathway 16%

Medicine and Dentistry

• Endoplasmic Reticulum Stress 100%
• Beta Cell 100%
• Wolfram Syndrome 100%
• Diabetes 50%
• Endoplasmic reticulum 33%
• Cell Death 33%
• Unfolded Protein Response 33%
• Cytokine 16%
• Inflammatory Cytokine 16%
• Serositis 16%
• Secretion (Process) 16%
• Neurodegeneration 16%
• Macrophage 16%
• Genetic Disorder 16%
• Insulin Dependent Diabetes Mellitus 16%
• Gene Expression 16%
• Pancreatic Islet 16%
• Membrane Protein 16%
• Calpain 16%
• Anti-Inflammatory Drug 16%
• Hearing Impairment 16%
• Chemokine 16%
• Diabetes Insipidus 16%
• Optic Nerve Atrophy 16%
• Calcium Depletion 16%

Biochemistry, Genetics and Molecular Biology

• Endoplasmic Reticulum Stress 100%
• Wolfram Syndrome 100%
• WFS1 100%
• Cell Death 33%
• Unfolded Protein Response 33%
• Cytokine 16%
• Secretion (Process) 16%
• Knockout Mouse 16%
• Gene Expression 16%
• Genetic Disorder 16%
• Membrane Protein 16%
• Transmembrane Protein 16%
• Macrophage 16%
• Calpain 16%
• Chemokine 16%
• Proinflammatory Cytokine 16%