Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection

Marina Cella, Rachel Presti, William Vermi, Kerry Lavender, Emma Turnbull, Christina Ochsenbauer-Jambor, John C. Kappes, Guido Ferrari, Lisa Kessels, Ian Williams, Andrew J. McMichael, Barton F. Haynes, Persephone Borrow, Marco Colonna

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The hallmark of chronic viral infections is a progressive exhaustion of antigen-specific CD8+ T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8+ T cells that makes them dysfunctional. Here, we show that during human chronic HIV-1 infection, a CD8+ T-cell positive costimulatory pathway mediated by DNAX-activating molecule-1 is also disrupted. Thus, DNAX-activating molecule-1 downregulation on CD8+ T cells aggravates the impairment of CTL effector function in chronic HIV-1 infection.

Original languageEnglish
Pages (from-to)949-954
Number of pages6
JournalEuropean Journal of Immunology
Volume40
Issue number4
DOIs
StatePublished - Apr 1 2010

Keywords

  • Co-stimulation
  • Exhaustion
  • HIV-1

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    Cella, M., Presti, R., Vermi, W., Lavender, K., Turnbull, E., Ochsenbauer-Jambor, C., Kappes, J. C., Ferrari, G., Kessels, L., Williams, I., McMichael, A. J., Haynes, B. F., Borrow, P., & Colonna, M. (2010). Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection. European Journal of Immunology, 40(4), 949-954. https://doi.org/10.1002/eji.200940234