Abstract
The hallmark of chronic viral infections is a progressive exhaustion of antigen-specific CD8+ T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8+ T cells that makes them dysfunctional. Here, we show that during human chronic HIV-1 infection, a CD8+ T-cell positive costimulatory pathway mediated by DNAX-activating molecule-1 is also disrupted. Thus, DNAX-activating molecule-1 downregulation on CD8+ T cells aggravates the impairment of CTL effector function in chronic HIV-1 infection.
Original language | English |
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Pages (from-to) | 949-954 |
Number of pages | 6 |
Journal | European Journal of Immunology |
Volume | 40 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2010 |
Keywords
- Co-stimulation
- Exhaustion
- HIV-1