Loss of core 1-derived O-glycans decreases breast cancer development in mice

Kai Song, Brett H. Herzog, Jianxin Fu, Minjia Sheng, Kirk Bergstrom, J. Michael McDaniel, Yuji Kondo, Samuel McGee, Xiaofeng Cai, Ping Li, Hong Chen, Lijun Xia

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Mucin-type core 1-derived O-glycans, one of the major types of O-glycans, are highly expressed in mammary gland epithelium. Abnormal O-glycans such as Tn antigen are found in over 90% of breast cancers; however, the in vivo role of these aberrant O-glycans in the etiology of breast cancer is unclear. We generated mice with mammary epithelial specific deletion of core 1-derived O-glycans. By crossing with two spontaneous mouse breast cancer models, we determined that loss of core 1-derived O-glycans delays the onset and progression of breast cancer development. Deficiency of core 1 O-glycosylation impaired the localization of Muc1, a major O-glycoprotein, on the apical surfaces of mammary epithelium. Signaling mediated by Muc1, which is critical for breast cancer development, was also defective in the absence of core 1 O-glycans. This study reveals an unexpected role of core 1-derived O-glycans in breast cancer development in mice.

Original languageEnglish
Pages (from-to)20159-20166
Number of pages8
JournalJournal of Biological Chemistry
Volume290
Issue number33
DOIs
StatePublished - Aug 14 2015

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