@article{ccb81310dadb4c66aa990786d67e535b,
title = "Loss of Brain Aerobic Glycolysis in Normal Human Aging",
abstract = "The normal aging human brain experiences global decreases in metabolism, but whether this affects the topography of brain metabolism is unknown. Here we describe PET-based measurements of brain glucose uptake, oxygen utilization, and blood flow in cognitively normal adults from 20 to 82 years of age. Age-related decreases in brain glucose uptake exceed that of oxygen use, resulting in loss of brain aerobic glycolysis (AG). Whereas the topographies of total brain glucose uptake, oxygen utilization, and blood flow remain largely stable with age, brain AG topography changes significantly. Brain regions with high AG in young adults show the greatest change, as do regions with prolonged developmental transcriptional features (i.e., neoteny). The normal aging human brain thus undergoes characteristic metabolic changes, largely driven by global loss and topographic changes in brain AG.",
keywords = "aerobic glycolysis, brain aging, brain metabolism, neoteny",
author = "Goyal, {Manu S.} and Vlassenko, {Andrei G.} and Blazey, {Tyler M.} and Yi Su and Couture, {Lars E.} and Durbin, {Tony J.} and Bateman, {Randall J.} and Benzinger, {Tammie L.S.} and Morris, {John C.} and Raichle, {Marcus E.}",
note = "Funding Information: We are continually grateful for our participants{\textquoteright} time and effort in this and other studies. We are also thankful for useful discussions on this work with Anish Mitra and Dr. Avi Snyder. The data presented here were the result of several independently funded efforts, including grants from the Barnes-Jewish Hospital Foundation , Charles F. and Joanne Knight , the James S. McDonnell Foundation , and the McDonnell Center for Systems Neuroscience ( 22-3922-26239N ); the Radiological Society of North America ; and the NIH ( NS06833 , NS057901 , NS048056 , MH077967 , P50AG005681 , P01AG003991 , P01AG26276 , UF1AG032438 , UL1TR000448 , P30NS098577 , and R01EB009352 ). Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",
year = "2017",
month = aug,
day = "1",
doi = "10.1016/j.cmet.2017.07.010",
language = "English",
volume = "26",
pages = "353--360.e3",
journal = "Cell Metabolism",
issn = "1550-4131",
number = "2",
}