Loss of Brain Aerobic Glycolysis in Normal Human Aging

Manu S. Goyal; Andrei G. Vlassenko; Tyler M. Blazey; Yi Su; Lars E. Couture; Tony J. Durbin; Randall J. Bateman; Tammie L.S. Benzinger; John C. Morris; Marcus E. Raichle

doi:10.1016/j.cmet.2017.07.010

Loss of Brain Aerobic Glycolysis in Normal Human Aging

Manu S. Goyal, Andrei G. Vlassenko, Tyler M. Blazey, Yi Su, Lars E. Couture, Tony J. Durbin, Randall J. Bateman, Tammie L.S. Benzinger, John C. Morris, Marcus E. Raichle

Research output: Contribution to journal › Article › peer-review

199 Scopus citations

Abstract

The normal aging human brain experiences global decreases in metabolism, but whether this affects the topography of brain metabolism is unknown. Here we describe PET-based measurements of brain glucose uptake, oxygen utilization, and blood flow in cognitively normal adults from 20 to 82 years of age. Age-related decreases in brain glucose uptake exceed that of oxygen use, resulting in loss of brain aerobic glycolysis (AG). Whereas the topographies of total brain glucose uptake, oxygen utilization, and blood flow remain largely stable with age, brain AG topography changes significantly. Brain regions with high AG in young adults show the greatest change, as do regions with prolonged developmental transcriptional features (i.e., neoteny). The normal aging human brain thus undergoes characteristic metabolic changes, largely driven by global loss and topographic changes in brain AG.

Original language	English
Pages (from-to)	353-360.e3
Journal	Cell metabolism
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2017.07.010
State	Published - Aug 1 2017

Keywords

aerobic glycolysis
brain aging
brain metabolism
neoteny

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title = "Loss of Brain Aerobic Glycolysis in Normal Human Aging",

abstract = "The normal aging human brain experiences global decreases in metabolism, but whether this affects the topography of brain metabolism is unknown. Here we describe PET-based measurements of brain glucose uptake, oxygen utilization, and blood flow in cognitively normal adults from 20 to 82 years of age. Age-related decreases in brain glucose uptake exceed that of oxygen use, resulting in loss of brain aerobic glycolysis (AG). Whereas the topographies of total brain glucose uptake, oxygen utilization, and blood flow remain largely stable with age, brain AG topography changes significantly. Brain regions with high AG in young adults show the greatest change, as do regions with prolonged developmental transcriptional features (i.e., neoteny). The normal aging human brain thus undergoes characteristic metabolic changes, largely driven by global loss and topographic changes in brain AG.",

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AU - Vlassenko, Andrei G.

AU - Blazey, Tyler M.

AU - Su, Yi

AU - Couture, Lars E.

AU - Durbin, Tony J.

AU - Bateman, Randall J.

AU - Benzinger, Tammie L.S.

AU - Morris, John C.

AU - Raichle, Marcus E.

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AB - The normal aging human brain experiences global decreases in metabolism, but whether this affects the topography of brain metabolism is unknown. Here we describe PET-based measurements of brain glucose uptake, oxygen utilization, and blood flow in cognitively normal adults from 20 to 82 years of age. Age-related decreases in brain glucose uptake exceed that of oxygen use, resulting in loss of brain aerobic glycolysis (AG). Whereas the topographies of total brain glucose uptake, oxygen utilization, and blood flow remain largely stable with age, brain AG topography changes significantly. Brain regions with high AG in young adults show the greatest change, as do regions with prolonged developmental transcriptional features (i.e., neoteny). The normal aging human brain thus undergoes characteristic metabolic changes, largely driven by global loss and topographic changes in brain AG.

KW - aerobic glycolysis

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Loss of Brain Aerobic Glycolysis in Normal Human Aging

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Keywords

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