TY - JOUR
T1 - Looking in the rear view mirror when conversing with back seat drivers
T2 - The EXCITE Trial revisited
AU - L. Wolf, Steven
AU - J. Winstein, Carolee
AU - Miller, J. Phillip
AU - Blanton, Sarah
AU - Clark, Patricia C.
AU - Nichols-Larsen, Deborah
PY - 2007/9
Y1 - 2007/9
N2 - The initial Point of View: Directions for Research (Neurorehabilitation and Neural Repair, 2007;21:3-13) identified confounders that might limit the impact that rehabilitation multicenter clinical trials may have upon altering practice patterns. Part of that viewpoint addressed the Extremity Constraint Induced Therapy Evaluation (EXCITE) Trial and highlighted some of its perceived strengths and limitations. The present Point of View expands upon factors worthy of consideration in planning and executing clinical trials in neurorehabilitation based upon experiences encountered by the EXCITE team. Cost factors and patient attributes, both of which profoundly influence the ability of clinical researchers to execute the ideal study, are among these factors. In particular, the costs associated with large trials necessitate compromise in study design or implementation, resulting in a dichotomy between what should be undertaken and what can be accomplished.
AB - The initial Point of View: Directions for Research (Neurorehabilitation and Neural Repair, 2007;21:3-13) identified confounders that might limit the impact that rehabilitation multicenter clinical trials may have upon altering practice patterns. Part of that viewpoint addressed the Extremity Constraint Induced Therapy Evaluation (EXCITE) Trial and highlighted some of its perceived strengths and limitations. The present Point of View expands upon factors worthy of consideration in planning and executing clinical trials in neurorehabilitation based upon experiences encountered by the EXCITE team. Cost factors and patient attributes, both of which profoundly influence the ability of clinical researchers to execute the ideal study, are among these factors. In particular, the costs associated with large trials necessitate compromise in study design or implementation, resulting in a dichotomy between what should be undertaken and what can be accomplished.
KW - Constraint-induced movement therapy
KW - Hemiplegia
KW - Randomized clinical trials
KW - Rehabilitation
KW - Stroke
KW - Upper extremity
UR - http://www.scopus.com/inward/record.url?scp=34547851761&partnerID=8YFLogxK
U2 - 10.1177/1545968307306238
DO - 10.1177/1545968307306238
M3 - Review article
C2 - 17644651
AN - SCOPUS:34547851761
SN - 1545-9683
VL - 21
SP - 379
EP - 387
JO - Neurorehabilitation and neural repair
JF - Neurorehabilitation and neural repair
IS - 5
ER -