TY - JOUR
T1 - Longitudinal Study after Sputnik V Vaccination Shows Durable SARS-CoV-2 Neutralizing Antibodies and Reduced Viral Variant Escape to Neutralization over Time
AU - Gonzalez Lopez Ledesma, María M.
AU - Sanchez, Lautaro
AU - Ojeda, Diego S.
AU - Rouco, Santiago Oviedo
AU - Rossi, Andrés H.
AU - Varese, Augusto
AU - Mazzitelli, Ignacio
AU - Pascuale, Carla A.
AU - Miglietta, Esteban A.
AU - Rodríguez, Pamela E.
AU - Pallarés, Horacio M.
AU - Costa Navarro, Guadalupe S.
AU - Caramelo, Julio J.
AU - Rothlauf, Paul W.
AU - Liu, Zhuoming
AU - Bloyet, Louis Marie
AU - Pontelli, Marjorie Cornejo
AU - Rasetto, Natali B.
AU - Wenker, Shirley D.
AU - Ramis, Lila Y.
AU - Bialer, Magalí G.
AU - de Leone, María Jose
AU - Esteban Hernando, C.
AU - Bianchimano, Luciana
AU - Ríos, Antonella S.
AU - Cienfuegos, María Soledad Treffinger
AU - Rodriguez García, Diana R.
AU - Longueira, Yesica
AU - Laufer, Natalia
AU - Alvarez, Diego
AU - Ceballos, Ana
AU - Ochoa, Valeria
AU - Monzani, Cecilia
AU - Turk, Gariela
AU - Salvatori, Melina
AU - Carradori, Jorge
AU - Prost, Katherine
AU - Rima, Alejandra
AU - Varela, Claudia
AU - Ercole, Regina
AU - Toro, Rosana I.
AU - Gutierrez, Sebastian
AU - Zubieta, Martín
AU - Acuña, Dolores
AU - Nabaes Jodar, Mercedes S.
AU - Torres, Carolina
AU - Mojsiejczuk, Laura
AU - Viegas, Mariana
AU - Velazquez, Pilar
AU - Testa, Clarisa
AU - Kreplak, Nicolas
AU - Yanovsky, Marcelo
AU - Whelan, Sean
AU - Geffner, Jorge
AU - Pifano, Marina
AU - Gamarnik, Andrea V.
N1 - Funding Information:
This work was supported by NIH (NIAID) R01.AI095175 and PICT-2017-1717, PICT-2015-2555, and Fondo para la Convergencia Estructural del Mercosur (FOCEM) to A.V.G. and by the National Ministry of Science Technology and Innovation of Argentina.
Publisher Copyright:
Copyright © 2022 Gonzalez Lopez Ledesma et al.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Recent studies have shown a temporal increase in the neutralizing antibody potency and breadth to SARS-CoV-2 variants in coronavirus disease 2019 (COVID-19) convalescent individuals. Here, we examined longitudinal antibody responses and viral neutralizing capacity to the B.1 lineage virus (Wuhan related), to variants of concern (VOC; Alpha, Beta, Gamma, and Delta), and to a local variant of interest (VOI; Lambda) in volunteers receiving the Sputnik V vaccine in Argentina. Longitudinal serum samples (N = 536) collected from 118 volunteers obtained between January and October 2021 were used. The analysis indicates that while anti-spike IgG levels significantly wane over time, the neutralizing capacity for the Wuhan-related lineages of SARS-CoV-2 and VOC is maintained within 6 months of vaccination. In addition, an improved antibody cross-neutralizing ability for circulating variants of concern (Beta and Gamma) was observed over time postvaccination. The viral variants that displayed higher escape to neutralizing antibodies with respect to the original virus (Beta and Gamma variants) were the ones showing the largest increase in susceptibility to neutralization over time after vaccination. Our observations indicate that serum neutralizing antibodies are maintained for at least 6 months and show a reduction of VOC escape to neutralizing antibodies over time after vaccination. IMPORTANCE Vaccines have been produced in record time for SARS-CoV-2, offering the possibility of halting the global pandemic. However, inequalities in vaccine accessibility in different regions of the world create a need to increase international cooperation. Sputnik V is a recombinant adenovirus-based vaccine that has been widely used in Argentina and other developing countries, but limited information is available about its elicited immune responses. Here, we examined longitudinal antibody levels and viral neutralizing capacity elicited by Sputnik V vaccination. Using a cohort of 118 volunteers, we found that while anti-spike antibodies wane over time, the neutralizing capacity to viral variants of concern and local variants of interest is maintained within 4 months of vaccination. In addition, we observed an increased cross-neutralization activity over time for the Beta and Gamma variants. This study provides valuable information about the immune response generated by a vaccine platform used in many parts of the world.
AB - Recent studies have shown a temporal increase in the neutralizing antibody potency and breadth to SARS-CoV-2 variants in coronavirus disease 2019 (COVID-19) convalescent individuals. Here, we examined longitudinal antibody responses and viral neutralizing capacity to the B.1 lineage virus (Wuhan related), to variants of concern (VOC; Alpha, Beta, Gamma, and Delta), and to a local variant of interest (VOI; Lambda) in volunteers receiving the Sputnik V vaccine in Argentina. Longitudinal serum samples (N = 536) collected from 118 volunteers obtained between January and October 2021 were used. The analysis indicates that while anti-spike IgG levels significantly wane over time, the neutralizing capacity for the Wuhan-related lineages of SARS-CoV-2 and VOC is maintained within 6 months of vaccination. In addition, an improved antibody cross-neutralizing ability for circulating variants of concern (Beta and Gamma) was observed over time postvaccination. The viral variants that displayed higher escape to neutralizing antibodies with respect to the original virus (Beta and Gamma variants) were the ones showing the largest increase in susceptibility to neutralization over time after vaccination. Our observations indicate that serum neutralizing antibodies are maintained for at least 6 months and show a reduction of VOC escape to neutralizing antibodies over time after vaccination. IMPORTANCE Vaccines have been produced in record time for SARS-CoV-2, offering the possibility of halting the global pandemic. However, inequalities in vaccine accessibility in different regions of the world create a need to increase international cooperation. Sputnik V is a recombinant adenovirus-based vaccine that has been widely used in Argentina and other developing countries, but limited information is available about its elicited immune responses. Here, we examined longitudinal antibody levels and viral neutralizing capacity elicited by Sputnik V vaccination. Using a cohort of 118 volunteers, we found that while anti-spike antibodies wane over time, the neutralizing capacity to viral variants of concern and local variants of interest is maintained within 4 months of vaccination. In addition, we observed an increased cross-neutralization activity over time for the Beta and Gamma variants. This study provides valuable information about the immune response generated by a vaccine platform used in many parts of the world.
KW - COVID-19
KW - SARS CoV-2
KW - Sputnik V
KW - Viral variants
UR - http://www.scopus.com/inward/record.url?scp=85125937477&partnerID=8YFLogxK
U2 - 10.1128/MBIO.03442-21
DO - 10.1128/MBIO.03442-21
M3 - Article
C2 - 35073758
AN - SCOPUS:85125937477
VL - 13
JO - mBio
JF - mBio
SN - 2161-2129
IS - 1
M1 - e03442
ER -