TY - JOUR
T1 - Longitudinal comparison of diffusion tensor imaging parameters and neuropsychological measures following endoscopic third ventriculostomy for hydrocephalus. Case report
AU - Buckley, Robert T.
AU - Yuan, Weihong
AU - Mangano, Francesco T.
AU - Phillips, Jannel M.
AU - Powell, Stephanie
AU - McKinstry, Robert C.
AU - Rajagopal, Akila
AU - Jones, Blaise V.
AU - Holland, Scott
AU - Limbrick, David D.
PY - 2012/6
Y1 - 2012/6
N2 - The authors report the case of a 25-month-old boy who underwent endoscopic third ventriculostomy (ETV) for hydrocephalus resulting from aqueductal stenosis. The patient's recovery was monitored longitudinally and prospectively using MR diffusion tensor imaging (DTI) and formal neuropsychological testing. Despite minimal change in ventricle size, improvement in the DTI characteristics and neurodevelopmental trajectory was observed following ETV. These data support the use of DTI as a biomarker to assess therapeutic response in children undergoing surgical treatment for hydrocephalus. In the patient featured in this report, DTI appeared to provide more information regarding postoperative neurodevelopmental outcome than ventricle size alone.
AB - The authors report the case of a 25-month-old boy who underwent endoscopic third ventriculostomy (ETV) for hydrocephalus resulting from aqueductal stenosis. The patient's recovery was monitored longitudinally and prospectively using MR diffusion tensor imaging (DTI) and formal neuropsychological testing. Despite minimal change in ventricle size, improvement in the DTI characteristics and neurodevelopmental trajectory was observed following ETV. These data support the use of DTI as a biomarker to assess therapeutic response in children undergoing surgical treatment for hydrocephalus. In the patient featured in this report, DTI appeared to provide more information regarding postoperative neurodevelopmental outcome than ventricle size alone.
KW - Diffusion tensor imaging
KW - Endoscopic third ventriculostomy
KW - Hydrocephalus
KW - Neuropsychological outcome
UR - http://www.scopus.com/inward/record.url?scp=84861813795&partnerID=8YFLogxK
U2 - 10.3171/2012.2.PEDS11331
DO - 10.3171/2012.2.PEDS11331
M3 - Article
C2 - 22656255
AN - SCOPUS:84861813795
SN - 1933-0707
VL - 9
SP - 630
EP - 635
JO - Journal of Neurosurgery: Pediatrics
JF - Journal of Neurosurgery: Pediatrics
IS - 6
ER -