@article{404c69eac1b14afa815a6a2d18e0e568,
title = "Longitudinal changes in symptom-based female and male LUTS clusters",
abstract = "Aims: Lower urinary tract symptoms (LUTS) are diverse in type and variable in severity. We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clusters over time and tested associations with treatments received. Methods: Patient-reported LUTS and treatment data were collected at multiple time points between baseline and 12 months from the LURN Observational Cohort study. LUTS severity scores were calculated to summarize changes in symptom reporting over time in previously identified LURN clusters. Repeated measures linear regression models tested adjusted associations between cluster membership and severity scores. Results: Four-hundred seventeen men and 396 women were classified into improved, unchanged, and worsened symptoms between baseline and 12 months (men: 44.1%, 40.5%, and 15.3%; women: 55.8%, 33.1%, 11.1%, respectively). Improvement in LUTS severity scores varied by cluster (estimated adjusted mean change from baseline range: −.04 change in standard deviations of severity scores (ΔSD) to −.67 ΔSD). Prostate surgery was associated with improved severity scores (−.63 ΔSD) in men, while stress incontinence surgery was associated with improved severity scores (−.88 ΔSD) in women. Conclusion: Symptom improvement varied by cluster indicating response to therapy differs amongst subtypes of patients with LUTS. The differential improvement of patients in clusters suggests mechanistic differences between clusters and may aid in selecting more targeted treatments in the future.",
keywords = "lower urinary tract symptoms, symptom-based clustering, the Symptoms of Lower Urinary Tract Dysfunction Research Network Observational Cohort study, urinary incontinence",
author = "{the LURN Study Group} and Amundsen, {Cindy L.} and Helmuth, {Margaret E.} and Smith, {Abigail R.} and DeLancey, {John O.L.} and Bradley, {Catherine S.} and Flynn, {Kathryn E.} and Kenton, {Kimberly S.} and {Henry Lai}, H. and David Cella and Griffith, {James W.} and Andreev, {Victor P.} and {Eric Jelovsek}, J. and Liu, {Alice B.} and Ziya Kirkali and Yang, {Claire C.}",
note = "Funding Information: This is publication number 18 of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). The following individuals were instrumental in the planning and conduct of this study at each of the participating institutions. Duke University, Durham, North Carolina (DK097780): PI: Cindy L. Amundsen, MD, Kevin Weinfurt, PhD; Co-Is: Kathryn Flynn, PhD, Matthew O. Fraser, PhD, Todd Harshbarger, PhD, Eric Jelovsek, MD, Aaron Lentz, MD, Drew Peterson, MD, Nazema Siddiqui, MD, Alison Weidner, MD; Study Coordinators: Carrie Dombeck, MA, Robin Gilliam, MSW, Akira Hayes, Shantae McLean, MPH University of Iowa, Iowa City, IA (DK097772): PI: Karl Kreder, MD, MBA, Catherine S Bradley, MD, MSCE, Co-Is: Bradley A. Erickson, MD, MS, Susan K. Lutgendorf, PhD, Vince Magnotta, PhD, Michael A. O'Donnell, MD, Vivian Sung, MD; Study Coordinator: Ahmad Alzubaidi Northwestern University, Chicago, IL (DK097779): PIs: David Cella, Brian Helfand, MD, PhD; Co-Is: James W Griffith, PhD, Kimberly Kenton, MD, MS, Christina Lewicky-Gaupp, MD, Todd Parrish, PhD, Jennie Yufen Chen, PhD, Margaret Mueller, MD; Study Coordinators: Sarah Buono, Maria Corona, Beatriz Menendez, Alexis Siurek, Meera Tavathia, Veronica Venezuela, Azra Muftic, Pooja Talaty, Jasmine Nero. Dr. Helfand, Ms. Talaty, and Ms. Nero are at NorthShore University Health System. University of Michigan Health System, Ann Arbor, MI (DK099932): PI: J Quentin Clemens, MD, FACS, MSCI; Co-Is: Mitch Berger, MD, PhD, John DeLancey, MD, Dee Fenner, MD, Rick Harris, MD, Steve Harte, PhD, Anne P. Cameron, MD, John Wei, MD; Study Coordinators: Morgen Barroso, Linda Drnek, Greg Mowatt, Julie Tumbarello University of Washington, Seattle Washington (DK100011): PI: Claire Yang, MD; Co-I: John L. Gore, MD, MS; Study Coordinators: Alice Liu, MPH, Brenda Vicars, RN Washington University in St. Louis, St. Louis Missouri (DK100017): PI: Gerald L. Andriole, MD, H. Henry Lai; Co-I: Joshua Shimony, MD, PhD; Study Coordinators: Susan Mueller, RN, BSN, Heather Wilson, LPN, Deborah Ksiazek, BS, Aleksandra Klim, RN, MHS, CCRC National Institute of Diabetes and Digestive and Kidney Diseases, Division of Kidney, Urology, and Hematology, Bethesda, MD: Project Scientist: Ziya Kirkali MD; Project Officer: Christopher Mullins PhD; NIH Personnel: Tamara Bavendam, MD, Robert Star, MD, Jenna Norton Arbor Research Collaborative for Health, Data Coordinating Center (DK097776 and DK099879): PI: Robert Merion, MD, FACS; Co-Is: Victor Andreev, PhD, DSc, Brenda Gillespie, PhD, Gang Liu, PhD, Abigail Smith, PhD; Project Manager: Melissa Fava, MPA, PMP; Clinical Study Process Manager: Peg Hill-Callahan, BS, LSW; Clinical Monitor: Timothy Buck, BS, CCRP; Research Analysts: Margaret Helmuth, MA, Jon Wiseman, MS; Project Associate: Julieanne Lock, MLitt Funding Information: Dr Bradley and Dr DeLancey report grants from NIH/NIDDK, during the conduct of the study; Dr Jelovsek reports other from UpToDate outside the submitted work; Dr Yang reports grants from National Institutes of Health, during the conduct of the study; Dr Andreev reports grants from NIDDK, during the conduct of the study; Dr Lai reports grants from National Institutes of Health, during the conduct of the study; other from Medtronic, other from Allergan, personal fees from Aquinox, personal fees from Teva, outside the submitted work; Ms. Helmuth reports grants from NIDDK, during the conduct of the study; Dr Smith reports grants from NIDDK, during the conduct of the study. Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",
year = "2020",
month = jan,
day = "1",
doi = "10.1002/nau.24219",
language = "English",
volume = "39",
pages = "393--402",
journal = "Neurourology and Urodynamics",
issn = "0733-2467",
number = "1",
}