Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease

Ganesh M. Babulal; Ling Chen; Jason M. Doherty; Samantha A. Murphy; Ann M. Johnson; Catherine M. Roe

doi:10.3233/JAD-215708

Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease

Ganesh M. Babulal, Ling Chen, Jason M. Doherty, Samantha A. Murphy, Ann M. Johnson, Catherine M. Roe

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Alzheimer's disease (AD) studies in cognitively normal (CN) older adults age≥65 suggest depression is associated with molecular biomarkers (imaging and cerebrospinal fluid [CSF]). This study used linear mixed models (covariance pattern model) to assess whether baseline CSF biomarkers (Aβ42/Aβ40, t-Tau/Aβ42, p-Tau/Aβ42) predicted changes in non-depressed mood states in CN older adults (N = 248), with an average of three follow-up years. Participants with higher levels of CSF biomarkers developed more anger, anxiety, and fatigue over time compared to those with more normal levels. Non-depressed mood states in preclinical AD may be a prodrome for neuropsychiatric symptoms in symptomatic AD.

Original language	English
Pages (from-to)	141-148
Number of pages	8
Journal	Journal of Alzheimer's Disease
Volume	87
Issue number	1
DOIs	https://doi.org/10.3233/JAD-215708
State	Published - 2022

Keywords

Alzheimer's disease
anger
anxiety
biomarkers
cerebrospinal fluid
older adults

Access to Document

10.3233/JAD-215708

Cite this

@article{f5e9052e301b4ec3a275cbd4d1aa0291,

title = "Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease",

abstract = "Alzheimer's disease (AD) studies in cognitively normal (CN) older adults age≥65 suggest depression is associated with molecular biomarkers (imaging and cerebrospinal fluid [CSF]). This study used linear mixed models (covariance pattern model) to assess whether baseline CSF biomarkers (Aβ42/Aβ40, t-Tau/Aβ42, p-Tau/Aβ42) predicted changes in non-depressed mood states in CN older adults (N = 248), with an average of three follow-up years. Participants with higher levels of CSF biomarkers developed more anger, anxiety, and fatigue over time compared to those with more normal levels. Non-depressed mood states in preclinical AD may be a prodrome for neuropsychiatric symptoms in symptomatic AD.",

keywords = "Alzheimer's disease, anger, anxiety, biomarkers, cerebrospinal fluid, older adults",

author = "Babulal, {Ganesh M.} and Ling Chen and Doherty, {Jason M.} and Murphy, {Samantha A.} and Johnson, {Ann M.} and Roe, {Catherine M.}",

year = "2022",

doi = "10.3233/JAD-215708",

language = "English",

volume = "87",

pages = "141--148",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

number = "1",

}

TY - JOUR

T1 - Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease

AU - Babulal, Ganesh M.

AU - Chen, Ling

AU - Doherty, Jason M.

AU - Murphy, Samantha A.

AU - Johnson, Ann M.

AU - Roe, Catherine M.

PY - 2022

Y1 - 2022

N2 - Alzheimer's disease (AD) studies in cognitively normal (CN) older adults age≥65 suggest depression is associated with molecular biomarkers (imaging and cerebrospinal fluid [CSF]). This study used linear mixed models (covariance pattern model) to assess whether baseline CSF biomarkers (Aβ42/Aβ40, t-Tau/Aβ42, p-Tau/Aβ42) predicted changes in non-depressed mood states in CN older adults (N = 248), with an average of three follow-up years. Participants with higher levels of CSF biomarkers developed more anger, anxiety, and fatigue over time compared to those with more normal levels. Non-depressed mood states in preclinical AD may be a prodrome for neuropsychiatric symptoms in symptomatic AD.

AB - Alzheimer's disease (AD) studies in cognitively normal (CN) older adults age≥65 suggest depression is associated with molecular biomarkers (imaging and cerebrospinal fluid [CSF]). This study used linear mixed models (covariance pattern model) to assess whether baseline CSF biomarkers (Aβ42/Aβ40, t-Tau/Aβ42, p-Tau/Aβ42) predicted changes in non-depressed mood states in CN older adults (N = 248), with an average of three follow-up years. Participants with higher levels of CSF biomarkers developed more anger, anxiety, and fatigue over time compared to those with more normal levels. Non-depressed mood states in preclinical AD may be a prodrome for neuropsychiatric symptoms in symptomatic AD.

KW - Alzheimer's disease

KW - anger

KW - anxiety

KW - biomarkers

KW - cerebrospinal fluid

KW - older adults

UR - http://www.scopus.com/inward/record.url?scp=85129999084&partnerID=8YFLogxK

U2 - 10.3233/JAD-215708

DO - 10.3233/JAD-215708

M3 - Article

C2 - 35253769

AN - SCOPUS:85129999084

SN - 1387-2877

VL - 87

SP - 141

EP - 148

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 1

ER -

Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this