Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease

Ganesh M. Babulal, Ling Chen, Jason M. Doherty, Samantha A. Murphy, Ann M. Johnson, Catherine M. Roe

Research output: Contribution to journalArticlepeer-review

Abstract

Alzheimer's disease (AD) studies in cognitively normal (CN) older adults age≥65 suggest depression is associated with molecular biomarkers (imaging and cerebrospinal fluid [CSF]). This study used linear mixed models (covariance pattern model) to assess whether baseline CSF biomarkers (Aβ42/Aβ40, t-Tau/Aβ42, p-Tau/Aβ42) predicted changes in non-depressed mood states in CN older adults (N = 248), with an average of three follow-up years. Participants with higher levels of CSF biomarkers developed more anger, anxiety, and fatigue over time compared to those with more normal levels. Non-depressed mood states in preclinical AD may be a prodrome for neuropsychiatric symptoms in symptomatic AD.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalJournal of Alzheimer's Disease
Volume87
Issue number1
DOIs
StatePublished - 2022

Keywords

  • Alzheimer's disease
  • anger
  • anxiety
  • biomarkers
  • cerebrospinal fluid
  • older adults

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