Longitudinal analysis of pulmonary function in adults with sickle cell disease

Joshua J. Field; Jeffrey Glassberg; Annette Gilmore; Joanna Howard; Sameer Patankar; Yan Yan; Sally C. Davies; Michael R. DeBaun; Robert C. Strunk

doi:10.1002/ajh.21176

Longitudinal analysis of pulmonary function in adults with sickle cell disease

Joshua J. Field
, Jeffrey Glassberg
, Annette Gilmore
, Joanna Howard
, Sameer Patankar
, Yan Yan
, Sally C. Davies
, Michael R. DeBaun
, Robert C. Strunk

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV₁ for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.

Original language	English
Pages (from-to)	574-576
Number of pages	3
Journal	American journal of hematology
Volume	83
Issue number	7
DOIs	https://doi.org/10.1002/ajh.21176
State	Published - Jul 2008

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title = "Longitudinal analysis of pulmonary function in adults with sickle cell disease",

abstract = "Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV1 for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.",

author = "Field, \{Joshua J.\} and Jeffrey Glassberg and Annette Gilmore and Joanna Howard and Sameer Patankar and Yan Yan and Davies, \{Sally C.\} and DeBaun, \{Michael R.\} and Strunk, \{Robert C.\}",

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AU - Field, Joshua J.

AU - Glassberg, Jeffrey

AU - Gilmore, Annette

AU - Howard, Joanna

AU - Patankar, Sameer

AU - Yan, Yan

AU - Davies, Sally C.

AU - DeBaun, Michael R.

AU - Strunk, Robert C.

PY - 2008/7

Y1 - 2008/7

N2 - Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV1 for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.

AB - Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV1 for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.

UR - https://www.scopus.com/pages/publications/45749146298

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DO - 10.1002/ajh.21176

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SN - 0361-8609

VL - 83

SP - 574

EP - 576

JO - American journal of hematology

JF - American journal of hematology

IS - 7

ER -

Longitudinal analysis of pulmonary function in adults with sickle cell disease

Abstract

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