Longitudinal analysis of pulmonary function in adults with sickle cell disease

Joshua J. Field; Jeffrey Glassberg; Annette Gilmore; Joanna Howard; Sameer Patankar; Yan Yan; Sally C. Davies; Michael R. DeBaun; Robert C. Strunk

doi:10.1002/ajh.21176

Longitudinal analysis of pulmonary function in adults with sickle cell disease

Joshua J. Field, Jeffrey Glassberg, Annette Gilmore, Joanna Howard, Sameer Patankar, Yan Yan, Sally C. Davies, Michael R. DeBaun, Robert C. Strunk

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32 Scopus citations

Abstract

Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV₁ for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.

Original language	English
Pages (from-to)	574-576
Number of pages	3
Journal	American journal of hematology
Volume	83
Issue number	7
DOIs	https://doi.org/10.1002/ajh.21176
State	Published - Jul 2008

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abstract = "Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV1 for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.",

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AU - Glassberg, Jeffrey

AU - Gilmore, Annette

AU - Howard, Joanna

AU - Patankar, Sameer

AU - Yan, Yan

AU - Davies, Sally C.

AU - DeBaun, Michael R.

AU - Strunk, Robert C.

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AB - Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV1 for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.

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JO - American journal of hematology

JF - American journal of hematology

IS - 7

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Longitudinal analysis of pulmonary function in adults with sickle cell disease

Abstract

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