Longitudinal analysis of pulmonary function in adults with sickle cell disease

Joshua J. Field, Jeffrey Glassberg, Annette Gilmore, Joanna Howard, Sameer Patankar, Yan Yan, Sally C. Davies, Michael R. DeBaun, Robert C. Strunk

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV1 for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.

Original languageEnglish
Pages (from-to)574-576
Number of pages3
JournalAmerican journal of hematology
Issue number7
StatePublished - Jul 2008


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