TY - JOUR
T1 - Longitudinal analysis of developmental delays in children with neurofibromatosis type 1
AU - Wessel, Lauren E.
AU - Gao, Feng
AU - Gutmann, David H.
AU - Dunn, Courtney M.
PY - 2013/12
Y1 - 2013/12
N2 - Children with neurofibromatosis type 1 exhibit a variety of developmental delays. However, there is little information about the progression of these deficits over the course of development. Using the Parents' Evaluation of Developmental Status measurement tool, we assessed 124 infants (0-2 years of age), preschool-age children (3-5 years of age), and school-age children (6-8 years of age) with neurofibromatosis type 1 to define the natural history of delays. School-age children exhibited significantly more areas of delay than infants or preschool-age children. Delays in math, reading, gross motor, fine motor, and self-help development were observed more frequently in older than younger children. Finally, analysis of 43 subjects for whom longitudinal assessments were available revealed that children often migrated between delayed and nondelayed groups in all areas except gross motor development. Based on these findings, we advocate early developmental screening and intervention for this at-risk pediatric population, especially in the area of gross motor function.
AB - Children with neurofibromatosis type 1 exhibit a variety of developmental delays. However, there is little information about the progression of these deficits over the course of development. Using the Parents' Evaluation of Developmental Status measurement tool, we assessed 124 infants (0-2 years of age), preschool-age children (3-5 years of age), and school-age children (6-8 years of age) with neurofibromatosis type 1 to define the natural history of delays. School-age children exhibited significantly more areas of delay than infants or preschool-age children. Delays in math, reading, gross motor, fine motor, and self-help development were observed more frequently in older than younger children. Finally, analysis of 43 subjects for whom longitudinal assessments were available revealed that children often migrated between delayed and nondelayed groups in all areas except gross motor development. Based on these findings, we advocate early developmental screening and intervention for this at-risk pediatric population, especially in the area of gross motor function.
KW - development
KW - fine motor
KW - gross motor
KW - neurofibromatosis type 1
KW - physical therapy
UR - http://www.scopus.com/inward/record.url?scp=84887937735&partnerID=8YFLogxK
U2 - 10.1177/0883073812462885
DO - 10.1177/0883073812462885
M3 - Article
C2 - 23112244
AN - SCOPUS:84887937735
SN - 0883-0738
VL - 28
SP - 1689
EP - 1693
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 12
ER -