TY - JOUR
T1 - Long-term survival after transplantation of unrelated donor peripheral blood or bone marrow hematopoietic cells for hematologic malignancy
AU - Eapen, Mary
AU - Logan, Brent R.
AU - Appelbaum, Fredrick R.
AU - Antin, Joseph H.
AU - Anasetti, Claudio
AU - Couriel, Daniel R.
AU - Chen, Junfang
AU - Maziarz, Richard T.
AU - McCarthy, Philip L.
AU - Nakamura, Ryotaro
AU - Ratanatharathorn, Voravit
AU - Vij, Ravi
AU - Champlin, Richard E.
N1 - Publisher Copyright:
© 2015 American Society for Blood and Marrow Transplantation.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - We sought to determine whether differences in chronic graft-versus-host disease (GVHD) rates would lead to survival differences by comparing 2463 peripheral blood (PB) and 1713 bone marrow (BM) hematopoietic cell transplant recipients. Patients had acute leukemia, chronic myeloid leukemia (CML), or myelodysplastic syndrome, and they received myeloablative conditioning regimens and calcineurin-inhibitor GVHD prophylaxis. There were no significant differences in long-term survival after transplantation of PB and BM, except for patients in first chronic phase CML. For these patients, the 5-year rate of survival was lower after transplantation of PB compared with transplantation of BM (35% versus 56%, P= .001). Although mortality risks were higher in patients with chronic GVHD after both PB (hazard ratio [HR], 1.58; P < .001) and BM (HR 1.73; P < .001) transplantations, its effect on mortality did not differ by graft type (P= .42). BM is the preferred graft for first chronic phase CML, whereas as either graft is suitable for other leukemias.
AB - We sought to determine whether differences in chronic graft-versus-host disease (GVHD) rates would lead to survival differences by comparing 2463 peripheral blood (PB) and 1713 bone marrow (BM) hematopoietic cell transplant recipients. Patients had acute leukemia, chronic myeloid leukemia (CML), or myelodysplastic syndrome, and they received myeloablative conditioning regimens and calcineurin-inhibitor GVHD prophylaxis. There were no significant differences in long-term survival after transplantation of PB and BM, except for patients in first chronic phase CML. For these patients, the 5-year rate of survival was lower after transplantation of PB compared with transplantation of BM (35% versus 56%, P= .001). Although mortality risks were higher in patients with chronic GVHD after both PB (hazard ratio [HR], 1.58; P < .001) and BM (HR 1.73; P < .001) transplantations, its effect on mortality did not differ by graft type (P= .42). BM is the preferred graft for first chronic phase CML, whereas as either graft is suitable for other leukemias.
KW - Chronic graft-versus-host disease
KW - Leukemia
KW - Mortality
UR - http://www.scopus.com/inward/record.url?scp=84927166028&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2014.09.006
DO - 10.1016/j.bbmt.2014.09.006
M3 - Article
C2 - 25255165
AN - SCOPUS:84927166028
SN - 1083-8791
VL - 21
SP - 55
EP - 59
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 1
ER -