Long-term super-resolution imaging of amyloid structures using transient binding of thioflavin T

Kevin Spehar, Tianben Ding, Yuanzi Sun, Niraja Kedia, Jin Lu, George R. Nahass, Matthew D. Lew, Jan Bieschke

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Amyloids are implicated in Alzheimer’s disease but cannot be well resolved by standard light microscopy. We developed a tool to directly image native amyloid structures and dynamics at nanometer resolution over minutes to days.

Original languageEnglish
Title of host publicationOptical Molecular Probes, Imaging and Drug Delivery - Proceedings Biophotonics Congress
Subtitle of host publicationOptics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP)
PublisherOptical Society of America (OSA)
ISBN (Electronic)9781943580545
StatePublished - Apr 8 2019
EventOptical Molecular Probes, Imaging and Drug Delivery, OMP 2019 - Part of Biophotonics Congress: Optics in the Life Sciences Congress 2019 - Tucson, United States
Duration: Apr 14 2019Apr 17 2019

Publication series

NameOptical Molecular Probes, Imaging and Drug Delivery - Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP)

Conference

ConferenceOptical Molecular Probes, Imaging and Drug Delivery, OMP 2019 - Part of Biophotonics Congress: Optics in the Life Sciences Congress 2019
Country/TerritoryUnited States
CityTucson
Period04/14/1904/17/19

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