Long-term super-resolution imaging of amyloid structures using transient binding of Thioflavin T

Kevin Spehar, Tianben Ding, Yuanzi Sun, Niraja Kedia, Jin Lu, George R. Nahass, Matthew D. Lew, Jan Bieschke

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Amyloids are implicated in Alzheimer's disease but cannot be well resolved by standard light microscopy. We developed a tool to directly image native amyloid structures and dynamics at nanometer resolution over minutes to days.

Original languageEnglish
Title of host publicationOptical Molecular Probes, Imaging and Drug Delivery, OMP 2019
PublisherOptica Publishing Group (formerly OSA)
ISBN (Print)9781943580545
DOIs
StatePublished - 2019
EventOptical Molecular Probes, Imaging and Drug Delivery, OMP 2019 - Tucson, United States
Duration: Apr 14 2019Apr 17 2019

Publication series

NameOptics InfoBase Conference Papers
VolumePart F163-OMP 2019
ISSN (Electronic)2162-2701

Conference

ConferenceOptical Molecular Probes, Imaging and Drug Delivery, OMP 2019
Country/TerritoryUnited States
CityTucson
Period04/14/1904/17/19

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