TY - JOUR
T1 - Long-term Salvageability for Patients With Locally Recurrent Soft-Tissue Sarcomas
AU - Singer, Samuel
AU - Antman, Karen
AU - Corson, Joseph M.
AU - Eberlein, Timothy J.
PY - 1992/5
Y1 - 1992/5
N2 - Between 1971 and 1988, 39 patients were referred because of local recurrence of soft-tissue sarcomas and data from their patient records were analyzed to determine the parameters governing local recurrence. Mean follow-up was 11.1 years, with a mean time to local recurrence of 22 months. Twenty-one patients had local recurrence only, without metastatic disease. Salvage was provided for 14 (67%) of these patients after reexcision of local recurrence, and all 14 patients remained free of disease (mean follow-up, 112 months). We conclude that (1) excisional biopsy of tumors larger than 3 cm leads to potential contamination of clean tissue planes, limits ability to achieve an adequate margin of resection, and may compromise the definitive excision, and (2) in patients with local recurrence only, there is a high rate of long-term salvage (67% for follow-up of 9.3 years) after radical compartmental excision with or without postoperative radiation therapy.
AB - Between 1971 and 1988, 39 patients were referred because of local recurrence of soft-tissue sarcomas and data from their patient records were analyzed to determine the parameters governing local recurrence. Mean follow-up was 11.1 years, with a mean time to local recurrence of 22 months. Twenty-one patients had local recurrence only, without metastatic disease. Salvage was provided for 14 (67%) of these patients after reexcision of local recurrence, and all 14 patients remained free of disease (mean follow-up, 112 months). We conclude that (1) excisional biopsy of tumors larger than 3 cm leads to potential contamination of clean tissue planes, limits ability to achieve an adequate margin of resection, and may compromise the definitive excision, and (2) in patients with local recurrence only, there is a high rate of long-term salvage (67% for follow-up of 9.3 years) after radical compartmental excision with or without postoperative radiation therapy.
UR - http://www.scopus.com/inward/record.url?scp=0026708361&partnerID=8YFLogxK
U2 - 10.1001/archsurg.1992.01420050068009
DO - 10.1001/archsurg.1992.01420050068009
M3 - Article
C2 - 1575625
AN - SCOPUS:0026708361
SN - 0004-0010
VL - 127
SP - 548
EP - 554
JO - Archives of Surgery
JF - Archives of Surgery
IS - 5
ER -