Long-term efficacy of single-dose combinations of albendazole, ivermectin and diethylcarbamazine for the treatment of bancroftian filariasis

M. M. Ismail, R. L. Jayakody, G. J. Weil, Deepika Fernando, M. S.G. De Silva, G. A.C. De Silva, W. K. Balasooriya

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

In a 'blinded' trial (in Sri Lanka, 1996-98) of 47 male asymptomatic microfilaraemic subjects with Wuchereria bancrofti infection, the safety, tolerability and filaricidal efficacy of 3 single-dose combination regimens were compared: albendazole 400 mg with ivermectin 200 μg/kg, albendazole 400 mg with diethylcarbamazine citrate (DEC) 6 mg/kg or albendazole 600 mg with ivermectin 400 μg/kg. Treated subjects were followed-up for 24 months. This represents the first long-term study using combinations of albendazole with DEC or ivermectin in the above doses against bancroftian filariasis. All subjects had pretreatment microfilaria (mf) counts over 100/mL. All 3 treatments significantly reduced mf counts, with the albendazole-DEC-treated group showing the lowest mf levels at 18 and 24 months post-treatment. Filarial antigen tests suggested that all 3 treatments had significant activity against adult W. bancrofti; albendazole-DEC combination had the greatest activity according to this test, with antigen levels decreasing to 30·5% of pre-treatment antigen levels, 24 months after therapy. All 3 treatments were clinically safe and well tolerated. These results suggest that a single dose of albendazole 400 mg together with DEC 6 mg/kg is a safe and effective combination for suppression of microfilaraemia of bancroftian filariasis that could be considered for use in filariasis control programmes based on mass treatment of endemic populations.

Original languageEnglish
Pages (from-to)332-335
Number of pages4
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume95
Issue number3
DOIs
StatePublished - Jan 1 2001

Keywords

  • Albendazole
  • Chemotherapy
  • Diethylcarbamazine
  • Drug combinations
  • Filariasis
  • Ivermectin
  • Sri Lanka
  • Wuchereria bancrofti

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