Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia

Jeffrey E. Beal, Richard Olson, Lewis Lefkowitz, Linda Laubenstein, Paul Bellman, Bienvenido Yangco, Javier O. Morales, Robert Murphy, William Powderly, Terry F. Plasse, Kristen W. Mosdell, Kirk V. Shepard

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154 Scopus citations

Abstract

We studied the effect of long-term (12 months) dronabinol in 94 late- stage acquired immunodeficiency syndrome (AIDS) patients (mean CD4 count of 45/mm3) who previously participated in a 6-week study (placebo versus dronabinol). All patients received dronabinol orally - 2.5 mg twice daily (90%) or 2.5 mg once daily (10%). Appetite was measured using a visual analogue scale for hunger (VASH). Dronabinol was associated with consistent improvement in mean appetite. Patients previously treated with dronabinol continued to show improvement in VASH (percent change from baseline of 6- week trial; 48.6-76.1% at each month), whereas those previously treated with placebo exhibited substantial improvement in mean appetite, particularly during the initial 4 months of treatment (48.5-69.9%). Thereafter, dronabinol was associated with a VASH change at least twice baseline. Patients tended toward stable body weight for at lest 7 months. Adverse events were primarily related to known central nervous system effects of dronabinol. These data support long-term, safe use of dronabinol for anorexia associated with weight loss in patients with AIDS.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalJournal of Pain and Symptom Management
Volume14
Issue number1
DOIs
StatePublished - Jul 1 1997

Keywords

  • AIDS
  • Acquired immunodeficiency syndrome
  • Anorexia
  • Cachexia
  • Dronabinol
  • HIV
  • Human immunodeficiency virus

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    Beal, J. E., Olson, R., Lefkowitz, L., Laubenstein, L., Bellman, P., Yangco, B., Morales, J. O., Murphy, R., Powderly, W., Plasse, T. F., Mosdell, K. W., & Shepard, K. V. (1997). Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia. Journal of Pain and Symptom Management, 14(1), 7-14. https://doi.org/10.1016/S0885-3924(97)00038-9