Long-term behavioral recovery in Parkinsonian rats by an HSV vector expressing tyrosine hydroxylase

Matthew J. During, Janice R. Naegele, Karen L. O'Malley, Alfred I. Geller

Research output: Contribution to journalArticle

336 Scopus citations

Abstract

One therapeutic approach to treating Parkinson's disease is to convert endogenous striatal cells into levo-3,4-dihydroxyphenylalanine (L-dopa)-producing cells. A defective herpes simplex virus type 1 vector expressing human tyrosine hydroxylase was delivered into the partially denervated striatum of 6-hydroxydopamine-lesioned rats, used as a model of Parkinson's disease. Efficient behavioral and biochemical recovery was maintained for 1 year after gene transfer. Biochemical recovery included increases in both striatal tyrosine hydroxylase enzyme activity and in extracellular dopamine concentrations. Persistence of human tyrosine hydroxylase was revealed by expression of RNA and immunoreactivity.

Original languageEnglish
Pages (from-to)1399-1403
Number of pages5
JournalScience
Volume266
Issue number5189
DOIs
StatePublished - Jan 1 1994

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