In this study, we consider the problem of localizing focal brain injuries from surface electroencephalogram (EEG) recordings. To this end, we introduce a new analysis technique termed frequency-based intrinsic network dynamic reactivity (FINDR), which quantifies the extent to which different brain regions (defined in EEG channel space) are responsive to each other in terms of their frequency-domain activity. The technique generalizes the idea of EEG reactivity, a measure of how well EEG signals react/respond to exogenous stimuli. In the present work we generalize this notion to endogenous ‘stimuli,’ defined as short-time window frequency domain motifs that are most predominant on a per channel basis. For each of these predominant motifs, we quantify the variance of the activity in all other channels as a measure of ‘intrinsic reactivity’, under the hypothesis that channels proximal to injured regions will be systematically disassociated from other brain areas. We use this method as a front-end to a neural network classifier to predict injury location in a cohort of etiologically heterogeneous comatose patients. We achieve a 0.6 correlation between the predicted injury location and the actual brain injury. These results suggest a possibility of precise localization of brain injury using EEG.

Original languageEnglish
Article number102746
JournalBiomedical Signal Processing and Control
StatePublished - Jul 2021


  • Brain injury
  • Electroencephalography
  • Injury location
  • Spectral variance


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