Localized 13C‐{1H} NMR of rat liver In vivo using surface‐spoiling gradients

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Abstract

An NMR spectroscopy localization method that employs an inhomogeneous surface‐spoiling magnetic field gradient has been applied to detect the 13C‐{1H} signals from deep‐lying liver tissue of rat in vivo. The method requires small gradient driving currents (less than 1 amp) and short gradient periods (˜0.5–1.6 ms). Thus, it is not likely to suffer from induced eddy currents and can detect short T2 resonances. We demonstrate that by employing a pulsed surface‐spoiling gradient one can eliminate “contaminating” signals from the surface‐lying tissues (muscle, fat and skin) while still maintaining the resonance linewidth resolution for the deep‐lying tissue of interest (liver). The feasibility of using this localization approach to trace glucose conversion into glycogen is shown.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalNMR in biomedicine
Volume2
Issue number5-6
DOIs
StatePublished - Dec 1989

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