Localization of the Human Prostatic Secretory Protein PSP94 and its mRNA in the Epithelial Cells of the Prostate

ANOOP BRAR; MAJAMBU MBIKAY; FRANCINE SIROIS; SYLVIE FOURNIER; NABIL G. SEIDAH; MICHEL CHRÉTIEN

doi:10.1002/j.1939-4640.1988.tb01048.x

Localization of the Human Prostatic Secretory Protein PSP₉₄ and its mRNA in the Epithelial Cells of the Prostate

ANOOP BRAR, MAJAMBU MBIKAY, FRANCINE SIROIS, SYLVIE FOURNIER, NABIL G. SEIDAH, MICHEL CHRÉTIEN

Division of Infectious Disease

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25 Scopus citations

Abstract

The histologic distribution of a prostatic secretory protein of 94 amino acids (PSP₉₄) and its mRNA were examined simultaneously by conventional immunohistochemistry and in situ hybridization histochemistry. The results show localization of immunoreactive PSP₉₄ and its mRNA in the epithelial cells of the prostate gland, thus providing strong evidence of PSP₉₄ synthesis in these cells. Preliminary analysis of PSP₉₄ by radioimmunoassay and of its mRNA by Northern blot analysis indicates that PSP₉₄ biosynthesis in pathologic prostatic tissues is variable. The value of PSP₉₄ as a marker of prostate gland secretory activity is discussed. 1988 American Society of Andrology

Original language	English
Pages (from-to)	253-260
Number of pages	8
Journal	Journal of Andrology
Volume	9
Issue number	4
DOIs	https://doi.org/10.1002/j.1939-4640.1988.tb01048.x
State	Published - 1988

Keywords

epithelium
hybridization
immunohistochemistry
mRNA
man
prostate
protein
radioimmunoassay
secretion

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10.1002/j.1939-4640.1988.tb01048.x

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title = "Localization of the Human Prostatic Secretory Protein PSP94 and its mRNA in the Epithelial Cells of the Prostate",

abstract = "The histologic distribution of a prostatic secretory protein of 94 amino acids (PSP94) and its mRNA were examined simultaneously by conventional immunohistochemistry and in situ hybridization histochemistry. The results show localization of immunoreactive PSP94 and its mRNA in the epithelial cells of the prostate gland, thus providing strong evidence of PSP94 synthesis in these cells. Preliminary analysis of PSP94 by radioimmunoassay and of its mRNA by Northern blot analysis indicates that PSP94 biosynthesis in pathologic prostatic tissues is variable. The value of PSP94 as a marker of prostate gland secretory activity is discussed. 1988 American Society of Andrology",

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T1 - Localization of the Human Prostatic Secretory Protein PSP94 and its mRNA in the Epithelial Cells of the Prostate

AU - BRAR, ANOOP

AU - MBIKAY, MAJAMBU

AU - SIROIS, FRANCINE

AU - FOURNIER, SYLVIE

AU - SEIDAH, NABIL G.

AU - CHRÉTIEN, MICHEL

PY - 1988

Y1 - 1988

N2 - The histologic distribution of a prostatic secretory protein of 94 amino acids (PSP94) and its mRNA were examined simultaneously by conventional immunohistochemistry and in situ hybridization histochemistry. The results show localization of immunoreactive PSP94 and its mRNA in the epithelial cells of the prostate gland, thus providing strong evidence of PSP94 synthesis in these cells. Preliminary analysis of PSP94 by radioimmunoassay and of its mRNA by Northern blot analysis indicates that PSP94 biosynthesis in pathologic prostatic tissues is variable. The value of PSP94 as a marker of prostate gland secretory activity is discussed. 1988 American Society of Andrology

AB - The histologic distribution of a prostatic secretory protein of 94 amino acids (PSP94) and its mRNA were examined simultaneously by conventional immunohistochemistry and in situ hybridization histochemistry. The results show localization of immunoreactive PSP94 and its mRNA in the epithelial cells of the prostate gland, thus providing strong evidence of PSP94 synthesis in these cells. Preliminary analysis of PSP94 by radioimmunoassay and of its mRNA by Northern blot analysis indicates that PSP94 biosynthesis in pathologic prostatic tissues is variable. The value of PSP94 as a marker of prostate gland secretory activity is discussed. 1988 American Society of Andrology

KW - epithelium

KW - hybridization

KW - immunohistochemistry

KW - mRNA

KW - man

KW - prostate

KW - protein

KW - radioimmunoassay

KW - secretion

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DO - 10.1002/j.1939-4640.1988.tb01048.x

M3 - Article

C2 - 3182395

AN - SCOPUS:0023742966

SN - 0196-3635

VL - 9

SP - 253

EP - 260

JO - Journal of Andrology

JF - Journal of Andrology

IS - 4

ER -

Localization of the Human Prostatic Secretory Protein PSP₉₄ and its mRNA in the Epithelial Cells of the Prostate

Abstract

Keywords

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