Localization of technetium-99m diphosphonate in acutely injured muscle: Relationship to muscle calcium deposition

Barry A. Siegel; W. King Engel; E. Carolyn Derrer

doi:10.1212/wnl.27.3.230

Localization of technetium-99m diphosphonate in acutely injured muscle: Relationship to muscle calcium deposition

Barry A. Siegel, W. King Engel, E. Carolyn Derrer

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34 Scopus citations

Abstract

In rats with experimental ischemic myopathy, there was a significant correlation (r = 0.778, p < 0.001) between muscle uptake of techne tium-99m (^99mTc) diphosphonate and tissue calcium concentration. In addition, the accumulation of both calcium and ^99mTc-diphosphonate in acutely injured muscles was further increased in rats with vitamin D-induced hypercalcemia. Histologic studies demonstrated staining of damaged muscle fibers with alizarin red, indicating the presence of microcrystalline or ultramicrocrystalline calcium salts. Staining of muscle fibers was most intense in the outer marginal zones of individual microscopic infarcts. Our results suggest that the uptake of^99mTc-diphosphonate in acutely damaged skeletal muscle is directly related to the deposition of calcium salts within the injured muscle fibers.

Original language	English
Pages (from-to)	230-238
Number of pages	9
Journal	Neurology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1212/wnl.27.3.230
State	Published - Mar 1977

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title = "Localization of technetium-99m diphosphonate in acutely injured muscle: Relationship to muscle calcium deposition",

abstract = "In rats with experimental ischemic myopathy, there was a significant correlation (r = 0.778, p < 0.001) between muscle uptake of techne tium-99m (99mTc) diphosphonate and tissue calcium concentration. In addition, the accumulation of both calcium and 99mTc-diphosphonate in acutely injured muscles was further increased in rats with vitamin D-induced hypercalcemia. Histologic studies demonstrated staining of damaged muscle fibers with alizarin red, indicating the presence of microcrystalline or ultramicrocrystalline calcium salts. Staining of muscle fibers was most intense in the outer marginal zones of individual microscopic infarcts. Our results suggest that the uptake of99mTc-diphosphonate in acutely damaged skeletal muscle is directly related to the deposition of calcium salts within the injured muscle fibers.",

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T1 - Localization of technetium-99m diphosphonate in acutely injured muscle

T2 - Relationship to muscle calcium deposition

AU - Siegel, Barry A.

AU - Engel, W. King

AU - Derrer, E. Carolyn

PY - 1977/3

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N2 - In rats with experimental ischemic myopathy, there was a significant correlation (r = 0.778, p < 0.001) between muscle uptake of techne tium-99m (99mTc) diphosphonate and tissue calcium concentration. In addition, the accumulation of both calcium and 99mTc-diphosphonate in acutely injured muscles was further increased in rats with vitamin D-induced hypercalcemia. Histologic studies demonstrated staining of damaged muscle fibers with alizarin red, indicating the presence of microcrystalline or ultramicrocrystalline calcium salts. Staining of muscle fibers was most intense in the outer marginal zones of individual microscopic infarcts. Our results suggest that the uptake of99mTc-diphosphonate in acutely damaged skeletal muscle is directly related to the deposition of calcium salts within the injured muscle fibers.

AB - In rats with experimental ischemic myopathy, there was a significant correlation (r = 0.778, p < 0.001) between muscle uptake of techne tium-99m (99mTc) diphosphonate and tissue calcium concentration. In addition, the accumulation of both calcium and 99mTc-diphosphonate in acutely injured muscles was further increased in rats with vitamin D-induced hypercalcemia. Histologic studies demonstrated staining of damaged muscle fibers with alizarin red, indicating the presence of microcrystalline or ultramicrocrystalline calcium salts. Staining of muscle fibers was most intense in the outer marginal zones of individual microscopic infarcts. Our results suggest that the uptake of99mTc-diphosphonate in acutely damaged skeletal muscle is directly related to the deposition of calcium salts within the injured muscle fibers.

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Localization of technetium-99m diphosphonate in acutely injured muscle: Relationship to muscle calcium deposition

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