Localization of technetium-99m diphosphonate in acutely injured muscle: Relationship to muscle calcium deposition

Barry A. Siegel, W. King Engel, E. Carolyn Derrer

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

In rats with experimental ischemic myopathy, there was a significant correlation (r = 0.778, p < 0.001) between muscle uptake of techne tium-99m (99mTc) diphosphonate and tissue calcium concentration. In addition, the accumulation of both calcium and 99mTc-diphosphonate in acutely injured muscles was further increased in rats with vitamin D-induced hypercalcemia. Histologic studies demonstrated staining of damaged muscle fibers with alizarin red, indicating the presence of microcrystalline or ultramicrocrystalline calcium salts. Staining of muscle fibers was most intense in the outer marginal zones of individual microscopic infarcts. Our results suggest that the uptake of99mTc-diphosphonate in acutely damaged skeletal muscle is directly related to the deposition of calcium salts within the injured muscle fibers.

Original languageEnglish
Pages (from-to)230-238
Number of pages9
JournalNeurology
Volume27
Issue number3
DOIs
StatePublished - Mar 1977

Fingerprint

Dive into the research topics of 'Localization of technetium-99m diphosphonate in acutely injured muscle: Relationship to muscle calcium deposition'. Together they form a unique fingerprint.

Cite this