TY - JOUR
T1 - Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with alzheimer disease
AU - Shoghi-Jadid, Kooresh
AU - Small, Gary W.
AU - Agdeppa, Eric D.
AU - Kepe, Vladimir
AU - Ercoli, Linda M.
AU - Siddarth, Prabha
AU - Read, Stephen
AU - Satyamurthy, Nagichettiar
AU - Petric, Andrej
AU - Huang, Sung Cheng
AU - Barrio, Jorge R.
N1 - Funding Information:
This work is supported in part by Department of Energy Grant DE-FC0387-ER60615, the Charles A. Dana Foundation, the Alzheimer's Association Zenith Award, and The Institute for the Study of Aging, Inc.
PY - 2002
Y1 - 2002
N2 - The authors used 2-(1-[6-[(2-[18F]fluoroethyl(methyl)amino]- 2-naphthyl]ethylidene)malononitrile ([18F]FDDNP), a hydrophobic radiofluorinated derivative of 2-[1-[6-(dimethylamino)-2-naphthyl]ethylidene]malononitrile (DDNP), conjunction with positron emission tomography to determine the localization and load of neurofibrillary tangles (NFTs) and Β-amyloid senile plaques (APs) in the brains of living Alzheimer disease (AD) patients. Previous work illustrated the in vitro binding characteristics of [18F]FDDNP to synthetic Β-amyloid(1 -40) fibrils and to NFTs and APs in human AD brain specimens. In the present study, greater accumulation and slower clearance was observed in AP- and NFT-dense brain areas and correlated with lower memory performance scores. The relative residence time of the probe in brain regions affected by AD was significantly greater in patients with AD (n = 9) than in control subjects (n = 7; p = 0.0007). This noninvasive technique for monitoring AP and NFT development is expected to facilitate diagnostic assessment of patients with AD and assist in response-monitoring during experimental treatments.
AB - The authors used 2-(1-[6-[(2-[18F]fluoroethyl(methyl)amino]- 2-naphthyl]ethylidene)malononitrile ([18F]FDDNP), a hydrophobic radiofluorinated derivative of 2-[1-[6-(dimethylamino)-2-naphthyl]ethylidene]malononitrile (DDNP), conjunction with positron emission tomography to determine the localization and load of neurofibrillary tangles (NFTs) and Β-amyloid senile plaques (APs) in the brains of living Alzheimer disease (AD) patients. Previous work illustrated the in vitro binding characteristics of [18F]FDDNP to synthetic Β-amyloid(1 -40) fibrils and to NFTs and APs in human AD brain specimens. In the present study, greater accumulation and slower clearance was observed in AP- and NFT-dense brain areas and correlated with lower memory performance scores. The relative residence time of the probe in brain regions affected by AD was significantly greater in patients with AD (n = 9) than in control subjects (n = 7; p = 0.0007). This noninvasive technique for monitoring AP and NFT development is expected to facilitate diagnostic assessment of patients with AD and assist in response-monitoring during experimental treatments.
UR - http://www.scopus.com/inward/record.url?scp=84903202261&partnerID=8YFLogxK
U2 - 10.1097/00019442-200201000-00004
DO - 10.1097/00019442-200201000-00004
M3 - Article
AN - SCOPUS:84903202261
SN - 1064-7481
VL - 10
SP - 24
EP - 35
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 1
ER -