TY - JOUR
T1 - Localization of a gene for the human low-voltage EEG on 20q and genetic heterogeneity
AU - Steinlein, Ortrud
AU - Anokhin, Andrej
AU - Yping, Mao
AU - Schalt, Edda
AU - Vogel, Friedrich
N1 - Funding Information:
RMR6 (D20S20); Collaborative Research, Inc. (Bedford, MA), for the probe CRI-L355 (D20S15); Jens Kruger for helping with statistical analysis; Jurg Ott for providing us with the computer program HOMOG and for his valuable comments on linkage heterogeneity; Dave Curtis for his programs TABLE and PEDRAW; and Ulrike Barth-Witte, Margaret Baumann, Marie-Christine Mef-fert, and Holger Geupel for their excellent technical work. This study was supported by a grant from the Deutsche Forschungsge-meinschaft; A.A. was funded by the Alexander von Humboldt-Stiftung, Bonn.
PY - 1992/1
Y1 - 1992/1
N2 - The localization of a gene responsible for a normal variant of the human electroencephalogram to the distal part of chromosome 20q is reported. A linkage analysis, including 17 families with 191 individuals, tested with 73 RFLPs and 22 blood and serological markers, was performed for the low-voltage electroencephalogram. This is a normal variant of the human electroencephalogram with an autosomal dominant mode of inheritance. The results present strong evidence for close linkage with the highly polymorphic marker CMM6 (D20S19) and for genetic heterogeneity.
AB - The localization of a gene responsible for a normal variant of the human electroencephalogram to the distal part of chromosome 20q is reported. A linkage analysis, including 17 families with 191 individuals, tested with 73 RFLPs and 22 blood and serological markers, was performed for the low-voltage electroencephalogram. This is a normal variant of the human electroencephalogram with an autosomal dominant mode of inheritance. The results present strong evidence for close linkage with the highly polymorphic marker CMM6 (D20S19) and for genetic heterogeneity.
UR - http://www.scopus.com/inward/record.url?scp=0026553008&partnerID=8YFLogxK
U2 - 10.1016/0888-7543(92)90408-K
DO - 10.1016/0888-7543(92)90408-K
M3 - Article
C2 - 1346390
AN - SCOPUS:0026553008
SN - 0888-7543
VL - 12
SP - 69
EP - 73
JO - Genomics
JF - Genomics
IS - 1
ER -